The Protein Model Portal--a comprehensive resource for protein structure and model information.
The Protein Model Portal--a comprehensive resource for protein structure and model information.
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DOI：
10.1093/database/bat031
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Schwede T
中科院分区：
文献类型：
--
作者：
Haas J;Roth S;Arnold K;Kiefer F;Schmidt T;Bordoli L;Schwede T
蛋白质模型门户（PMP）的开发旨在通过提供方便和全面的蛋白质结构信息，促进生物医学研究中3D分子模型的有效使用。给定蛋白质的实验结构和理论模型可以同时搜索和分析结构变异性。通过提供结构信息的全面视图，PMP提供了将一致的评估和验证标准应用于蛋白质完整结构模型的机会。PMP是一个开放的项目，因此社区开发的新方法可以为PMP做出贡献，例如，用于创建同源模型的新建模服务器和用于模型验证的模型质量估计服务器。参与建模服务器的准确性由持续自动模型评估（CAMEO）项目持续评估。PMP提供了一个独特的界面来可视化蛋白质的结构覆盖，结合了理论模型和实验结构，允许直接评估模型质量及其实用性。该门户网站定期更新，并积极发展，包括计算结构生物学领域的最新方法。数据库URL：http://www.proteinmodelportal.org
The Protein Model Portal (PMP) has been developed to foster effective use of 3D molecular models in biomedical research by providing convenient and comprehensive access to structural information for proteins. Both experimental structures and theoretical models for a given protein can be searched simultaneously and analyzed for structural variability. By providing a comprehensive view on structural information, PMP offers the opportunity to apply consistent assessment and validation criteria to the complete set of structural models available for proteins. PMP is an open project so that new methods developed by the community can contribute to PMP, for example, new modeling servers for creating homology models and model quality estimation servers for model validation. The accuracy of participating modeling servers is continuously evaluated by the Continuous Automated Model EvaluatiOn (CAMEO) project. The PMP offers a unique interface to visualize structural coverage of a protein combining both theoretical models and experimental structures, allowing straightforward assessment of the model quality and hence their utility. The portal is updated regularly and actively developed to include latest methods in the field of computational structural biology. Database URL: http://www.proteinmodelportal.org