Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore
Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore
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DOI：
10.1128/jvi.02445-08
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发表时间：
2009-05-01
影响因子：
5.4
通讯作者：
Hibberd, Martin L.
中科院分区：
文献类型：
--
作者：
Schreiber, Mark J.;Holmes, Edward C.;Hibberd, Martin L.
登革热是人类最重要的新兴疾病之一，目前没有预防性疫苗或抗病毒治疗方法。虽然世界上三分之一的人口生活在感染的风险中，但对登革热病毒（DENV）在暴发情况下的模式和动态知之甚少。通过利用基因组数据，从一个深入研究的重大疫情，我们能够描述DENV的分子流行病学在一个独特的精细尺度的时间和空间分辨率。两种DENV血清型（DENV-1和DENV-3）和多组分基因型在2005年期间在新加坡发生的主要登革热流行病的初始爆发阶段同时传播并且具有相似的流行病学和进化概况。尽管DENV-1和DENV-3在病毒血症和临床结果方面存在差异，但在爆发之前、期间或之后没有证据表明适应性进化，表明生态或免疫因素而不是病毒学因素是流行动态的关键决定因素。
Dengue is one of the most important emerging diseases of humans, with no preventative vaccines or antiviral cures available at present. Although one-third of the world's population live at risk of infection, little is known about the pattern and dynamics of dengue virus (DENV) within outbreak situations. By exploiting genomic data from an intensively studied major outbreak, we are able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial resolution. Two DENV serotypes (DENV-1 and DENV-3), and multiple component genotypes, spread concurrently and with similar epidemiological and evolutionary profiles during the initial outbreak phase of a major dengue epidemic that took place in Singapore during 2005. Although DENV-1 and DENV-3 differed in viremia and clinical outcome, there was no evidence for adaptive evolution before, during, or after the outbreak, indicating that ecological or immunological rather than virological factors were the key determinants of epidemic dynamics.