PCTA, a pan-cancer cell line transcriptome atlas.
PCTA, a pan-cancer cell line transcriptome atlas.
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PCTA，泛癌细胞系转录组图谱。
DOI：
10.1016/j.canlet.2024.216808
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发表时间：
2024
期刊：
影响因子：
9.7
通讯作者：
Yu,Xiuping
中科院分区：
文献类型：
--
作者：
Cheng,Siyuan;Li,Lin;Yu,Xiuping
A substantial volume of RNA sequencing data have been generated from cancer cell lines. However, it requires specific bioinformatics skills to compare gene expression levels across cell lines. This has hindered non-bioinformaticians from fully utilizing these valuable datasets in their research. To bridge this gap, we established a curated Pan-cancer Cell Line Transcriptome Atlas (PCTA) dataset. This resource aims to provide a user-friendly platform, allowing researchers without extensive bioinformatics expertise to access and leverage the wealth of information within the dataset for their studies. The PCTA dataset encompasses the expression matrix of 24,965 genes, featuring data from 84,385 samples derived from 5677 studies. This comprehensive compilation spans 535 cell lines, representing a spectrum of 114 cancer types originating from 30 diverse tissue types. On UMAP plots, cell lines originating from the same type of tissue tend to cluster together, illustrating the dataset's ability to capture biological relationships. Additionally, an interactive and user-friendly web application (https://pcatools.shinyapps.io/PCTA_app/) was developed for researchers to explore the PCTA dataset. This platform allows users to examine the expression of their genes of interest across a diverse array of samples.
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使用从噬菌体 M13mp 模板合成的单链 [32P]DNA 探针进行高灵敏度 S1 作图。
影响因子：
3.5
作者：
J. Burke
通讯作者：
J. Burke
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影响因子：
5.3
作者：
H. Schalch;J. Gaskell;T. L. Smith;Daniel Cullen
通讯作者：
Daniel Cullen
影响因子：
3.5
作者：
DEBOER, HA;ZHANG, YZ;REDDY, CA
通讯作者：
REDDY, CA
来自 Phanerochaete chrysosporium 的锰依赖性过氧化物酶。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Pease,EA;Andrawis,A;Tien,M
通讯作者：
Tien,M
编码来自木质素降解担子菌 Phanerochaete chrysosporium 的锰过氧化物酶的 cDNA 的表征。
DOI：
10.1016/s0021-9258(18)83695-x
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
David Pribnow;M. Mayfield;Valerie J. Nipper;Julie A. Brown;Michael H. Gold
通讯作者：
Michael H. Gold