The effects of tritiated water on the bone marrow cells in mice.
The effects of tritiated water on the bone marrow cells in mice.
复制标题
氚水对小鼠骨髓细胞的影响。
DOI：
10.1269/jrr.29.238
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发表时间：
1988
影响因子：
2
通讯作者：
S. Hatakeyama
中科院分区：
文献类型：
--
作者：
T. Tsuchiya;T. Norimura;M. Nikaido;H. Kakihara;H. Yamamoto;S. Hatakeyama
将氚RBE/氚化水/CFUs/CFUc对小鼠造血组织的急性影响与暴露于6OCo γ辐射的影响进行了比较。用样品氧化剂直接测定骨髓中氚的活度，根据样品氧化剂中氚的活度计算吸收剂量。测定骨髓中有核细胞数量、集落形成单位-脾脏（cfu）、集落形成单位-培养（CFUc）和成纤维细胞集落形成单位（CFUf），以评价氚和60Co γ辐射对骨髓的影响。根据观察数据推导出剂量-反应曲线，计算出有核骨髓细胞、CFUs和CFUc在HTO和6OCo伽马辐射照射2天后氚β射线相对于6OCo伽马射线的RBE值分别为0.91、1.09和1.51。
Tritium RBE/Tritiated Water/CFUs/CFUc The acute effects on hematopoietic tissue in mice of a single administration of tritiated water were compared with the effects of exposure to 6OCo gamma radiation. The activity of tritium in the bone marrow was measured directly using a sample oxidizer and the absorbed dose was calculated from the amount of activity of tritium in it. The number of nucleated cells, colony forming unit-spleen (CFUs), colony forming unit-culture (CFUc), and fibroblastoid colony forming unit (CFUf) in bone marrow were determined to evaluate the effects of tritium and 60Co gamma radiation on bone marrow. The dose-response curves were derived from the observed data and the RBE values of tritium beta rays relative to 6OCo gamma rays were calculated to be 0.91, 1.09 and 1.51 for nucleated bone marrow cells, CFUs and CFUc, respectively, for 2 days exposure to HTO and 6OCo gamma radiation.