ANATOMICAL MAPPING OF THE CEREBELLAR NUCLEOCORTICAL PROJECTIONS IN THE RAT - A RETROGRADE LABELING STUDY
ANATOMICAL MAPPING OF THE CEREBELLAR NUCLEOCORTICAL PROJECTIONS IN THE RAT - A RETROGRADE LABELING STUDY
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DOI：
10.1002/cne.902880208
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发表时间：
1989-10-08
影响因子：
2.5
通讯作者：
ANGAUT, P
中科院分区：
文献类型：
--
作者：
BUISSERETDELMAS, C;ANGAUT, P
本文用麦胚凝集素-辣根过氧化物酶结合物逆行细胞标记法对小脑核皮质投射进行了分析。每个主要的核亚区似乎引起核皮质的预测。投射的皮质分布在这里是指矢状带。区域A、B和C与最近在大鼠中基于其橄榄皮质和皮质核投射的描述（Buisseret-Delmas，“88 a，B）一致。这里给出了区域D的相应描述。根据它们的分布，核皮质投射有三种类型：1）同侧，相互的; 2）非相互的; 3）对侧，与皮质核传入对称。倒向投影严格沿矢状方向排列，呈以下带状分布。A区分为两个分区。内侧A区接受来自内侧核（NM）内侧面的核传入。前叶和第Ⅵ小叶的外侧A区和后叶的外侧A区分别接受来自腹外侧核束和背外侧隆突的相互核传入。B区似乎没有接受核皮质投射。C区有三个亚区。C1由间位核的前、后分支（分别为NIA和NIP）的内侧三分之一供应。C2由NIA和NIP的中央三分之一提供。在吻尾侧，前叶和小叶VIII与NIA相连，小叶VI和VII与NIP相连。C3似乎连接到NIA的外侧三分之一。D区包含大鼠中外侧的三个亚区。D 0，以前没有描述过，是根据其来自主橄榄腹侧板内侧半的橄榄传入和Goodman等人（'63）的背外侧隆起上的皮质核投射来定义的。它接受来自背外侧隆起的相互核皮质传入。D1的橄榄传入来自主橄榄的背片。它与外侧核（NL）的外侧大细胞部分相互连接。D2是半球的最外侧亚区。其橄榄传入纤维来自主橄榄腹板的外半部。D2与NL的腹侧小细胞亚群相互连接。非互易投射的主要皮质区是外侧A区、C3和D1亚区。到外侧A区的非相互纤维来自NIA和NIP，到C3亚区的非相互纤维主要来自背外侧驼峰和外侧NL，到D1亚区的非相互纤维来自背外侧驼峰和外侧NIP。对称投射是对侧投射，主要连接NM和外侧Z区，但NIP和C区之间也有连接，NL和D区之间也有连接，但非常罕见。未发现背外侧隆起和外侧NIA和NIP的对称投射。
An analysis of the cerebellar nucleocortical projections was made by means of retrograde cellular labeling with wheat germ agglutinin-horseradish peroxidase conjugate. Each of the main nuclear subregions appears to give rise to nucleocortical projections. The cortical distribution of the projections is referred to here in term of sagittal zones. Zones A, B, and C conform to the recent description in the rat (Buisseret-Delmas, ''88a,b) on the basis of their olivocortical and corticonuclear projections. A corresponding description of zone D is given here. According to their distribution, three types of nucleocortical projections have been distinguished: 1) ipsilateral, reciprocal; 2) nonreciprocal; and 3) contralateral, symmetrical to the corticonuclear afferent. Reciprocal projections are strictly arranged in the sagittal direction, with the following zonal distribution. Zone A is subdivided into two subzones. Medial A zone receives its nuclear afferents from the medial aspect of the nucleus medialis (NM). The lateral A zone of the anterior lobe and lobule VI and that of the posterior lobe receive their reciprocal nuclear afferents from the ventrolateral NM and the dorsolateral protuberance, respectively. Zone B does not seem to receive nucleocortical projections. Zone C has three subzones in the rat. C1 is supplied from the medial third of the anterior and posterior subdivisions of the nucleus interpositus (NIA and NIP, respectively). C2 is supplied from the central third of the NIA and NIP. Rostrocaudally, the anterior lobe and lobule VIII are connected to the NIA, and lobules VI and VII to the NIP. C3 appears to be connected to the lateral third of NIA. Zone D contains three subzones mediolaterally in the rat. D0, not previously described, is defined on the basis of both its olivary afferent from the medial half of the ventral lamella of the principal olive and its corticonuclear projections onto the dorsolateral hump of Goodman et al. (''63). It receives a reciprocal nucleocortical afferent from the dorsolateral hump. D1 receives its olivary afferent from the dorsal lamella of the principal olive. It is reciprocally connected with the lateral, magnocellular part of the nucleus lateralis (NL). D2 is the most lateral subzone of the hemisphere. Its olivary afferent comes from the lateral half of the ventral lamella of the principal olive. D2 is reciproclaly connected with the ventral, parvicellular subdivision of NL. The main cortical reciiens for the nonreciprocal projections are the lateral A zone, the C3, and the D1 subzones. Nonreciprocal fibers to the lateral A zone come from the NIA and NIP, those to the C3 subzone mostly arise in the dorsolateral hump and the lateral NL, and those to the D1 subzone come from the dorsolateral hump as well as the lateral NIP. Symmetrical projections are contralateral projections that were found mainly connecting the NM and the lateral Z zone, but there were also connections between the NIP and zone C and, very rarely, the NL and zone D. Symmetrical projections from the dorsolateral hump and the lateral NIA and NIP have not been found.