The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis
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DOI：
10.1016/s0304-3940(00)01113-7
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发表时间：
2000-06-02
影响因子：
2.5
通讯作者：
Kamiya, H
中科院分区：
文献类型：
--
作者：
Ariumi, H;Saito, R;Kamiya, H
本实验研究了雪貂最后区（AP）速激肽NK-1受体在呕吐中的作用。在顺铂（10 mg/kg，i. p.）治疗动物，而不是对照动物。AP毁损后，中枢性吗啡呕吐和干呕次数显著减少（95%），外周性硫酸铜呕吐次数显著减少（54%）。用速激肽NK-1受体拮抗剂HSP-117（1.0 μ g）和CP-99，984（7.5 μ g）预处理AP可减少吗啡和硫酸铜诱导的呕吐和干呕次数。上述结果提示，AP中的NK-1受体参与吗啡和硫酸铜引起的呕吐。(C)2000由Elsevier Science爱尔兰有限公司出版。保留所有权利。
The role of tachykinin NK-1 receptors in the area postrema (AP) in emesis was examined in ferrets. Strong c-fos-like immunoreactivity was observed in the AP and nucleus tractus solitalius (NTS) in cisplatin (10 mg/kg, i.p.)-treated animals, but not in control animals. The number of the central emetogen morphine-induced vomits and retches was remarkably reduced (95%) and that of the peripheral emetogen copper sulphate-induced vomits was significantly (54%) reduced by AP lesion. Pretreatment with the tachykinin NK-1 receptor antagonists HSP-117 (1.0 mu g) and CP-99,984 (7.5 mu g) into the AP decreased the numbers of Vomits and retches induced by morphine and copper sulphate. These results suggest that NK-1 receptors in the AP are involved in the mechanism of emesis induced by morphine and copper sulphate. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.