Selective Copper-Catalyzed N-Arylation of Lactams with Arylboronic Acids under Base- and Ligand-Free Conditions
Selective Copper-Catalyzed N-Arylation of Lactams with Arylboronic Acids under Base- and Ligand-Free Conditions
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无碱和无配体条件下铜催化内酰胺与芳基硼酸的选择性 N-芳基化
DOI：
10.1055/s-0034-1380741
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
B. Sreedhar
中科院分区：
文献类型：
--
作者：
Thulasiram Bathini;Vikas S. Rawat;B. Sreedhar
摘要开发了一种铜催化的芳基硼酸与各种环尺寸内酰胺的氧化交叉偶联方法。N-芳基化的内酰胺在中等至优异的产率下获得，无需任何额外的碱、配体或添加剂。该反应显示出在羟基存在下对内酰胺的N-芳基化的完全选择性。
Abstract An oxidative copper-catalyzed cross-coupling of arylboronic acids with various ring-size lactams has been developed. The N-arylated lactams were obtained in moderate to excellent yields without any additional bases, ligands, or additives. This reaction shows complete selectivity for N-arylation of lactams in the presence of a hydroxyl group.