An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks
An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks
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DOI：
10.1038/s41565-017-0026-6
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发表时间：
2018-02-01
影响因子：
38.3
通讯作者：
Hamachi, Itaru
中科院分区：
文献类型：
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作者：
Shigemitsu, Hajime;Fujisaku, Takahiro;Hamachi, Itaru
新型软材料应包含多个超分子纳米结构，其对外部刺激的响应（例如组装和分解）可以独立控制。这种多组分系统存在于活细胞中，并控制由蛋白质、脂质、DNA 和 RNA 组成的各种超分子组装体的形成和分解，以响应外部刺激；然而，人造的对应物很难制造。在这里，我们提出了一种由自排序纳米纤维双网络组成的混合水凝胶，其中每个网络独立于另一个网络对所施加的外部刺激做出响应。通过添加 Na2S2O4 或细菌碱性磷酸酶，可以改变水凝胶的机械性能和封装蛋白质的释放速率。值得注意的是，凝胶的特性取决于施加外部刺激的顺序。包含正交刺激响应超分子组件的多组分水凝胶将适合设计新型自适应材料。
Novel soft materials should comprise multiple supramolecular nanostructures whose responses ( for example, assembly and disassembly) to external stimuli can be controlled independently. Such multicomponent systems are present in living cells and control the formation and break-up of a variety of supramolecular assemblies made of proteins, lipids, DNA and RNA in response to external stimuli; however, artificial counterparts are challenging to make. Here, we present a hybrid hydrogel consisting of a self-sorting double network of nanofibres in which each network responds to an applied external stimulus independent of the other. The hydrogel can be made to change its mechanical properties and rates of release of encapsulated proteins by adding Na2S2O4 or bacterial alkaline phosphatase. Notably, the properties of the gel depend on the order in which the external stimuli are applied. Multicomponent hydrogels comprising orthogonal stimulus-responsive supramolecular assemblies would be suitable for designing novel adaptive materials.