Reactive hyperemia following total and subtotal coronary occlusion in the awake dog.
Reactive hyperemia following total and subtotal coronary occlusion in the awake dog.
复制标题
清醒狗冠状动脉完全和次全闭塞后的反应性充血。
DOI：
10.1007/bf01908317
复制
发表时间：
1982
影响因子：
9.5
通讯作者：
Bache,RJ
中科院分区：
文献类型：
--
作者：
Sharon,MW;Bache,RJ
本研究检查了冠状动脉全闭塞和次全闭塞后的反应性充血。研究人员在清醒的狗身上使用电磁流量计和液压闭塞器对左旋冠状动脉进行了研究；用放射性核素标记微球检测灌注的区域分布。全闭塞和次全闭塞后反应性充血导致的平均血流量债务偿还率相似，分别为451±34%和492±51%。灌注分布差异有统计学意义，全闭塞后心内膜下与心外膜下血流之比为1.77±0.22，次全闭塞后为4.14±0.73 （p<0.01）。对反应性充血期间灌注模式的进一步检查表明，局部血流量债务与随后的反应性充血期间的血流量之间存在直接关系。这些数据表明，冠状动脉反应性充血并不均匀地发生在先前闭塞动脉所服务的血管床的整个分布中，而是与先前闭塞期间的灌注不足程度相关联。
This study examined the reactive hyperemia following total and subtotal coronary artery occlusions. Studies were carried out in awake dogs with electromagnetic flowmeters and hydraulic occluders on the left circumflex coronary artery; the regional distribution of perfusion was examined with radionuclide-labeled microspheres. Reactive hyperemia following total and subtotal occlusions resulted in similar mean blood flow debt repayments of 451±34% and 492±51%, respectively. However, the distribution of perfusion was markedly different, with the ratio of subendocardial to subepicardial blood flow being 1.77±0.22 after total occlusion and 4.14±0.73 after subtotal occlusion (p<0.01). Further examination of the pattern of perfusion during reactive hyperemia demonstrated a direct relationship between the local blood flow debt and blood flow during the subsequent reactive hyperemia. These data demonstrate that coronary reactive hyperemia does not occur uniformly throughout the distribution of the vascular bed served by the previously occluded artery, but rather is coupled to the degree of hypoperfusion during the preceding occlusion.