Polyunsaturated Fatty Acid (PUFA) Status in Pregnant Women: Associations with Sleep Quality, Inflammation, and Length of Gestation.
Polyunsaturated Fatty Acid (PUFA) Status in Pregnant Women: Associations with Sleep Quality, Inflammation, and Length of Gestation.
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DOI：
10.1371/journal.pone.0148752
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Belury MA
中科院分区：
文献类型：
--
作者：
Christian LM;Blair LM;Porter K;Lower M;Cole RM;Belury MA
将母体多不饱和脂肪酸(PUFA)状态与妊娠长度联系起来的机制路径描述得很差。这项研究考察了炎症和睡眠质量是否起到了中介作用，重点是抗炎的ω-3二十二碳六烯酸(DHA；22：6n3)和促炎的ω-6花生四烯酸(AA；20：4n6)。135名孕妇在怀孕20-27周时提供血样并完成匹兹堡睡眠质量指数(PSQI)。血清炎症标志物[白介素6、白介素8、肿瘤坏死因子α、白介素1β、C反应蛋白]采用高灵敏度试剂盒电化学发光法测定。较高的血清IL-8(95%CI=0.10，3.84)和较差的睡眠(95%CI=0.03，0.28)是DHA/AA比值降低与妊娠较短的显著中介因素。此外，从DHA：AA比率→睡眠→IL-8→孕期的一系列中介模型有统计学意义(95%CI=0.02，0.79)。在调整了抑郁症状、年龄、BMI、收入、种族和吸烟后，这些关系仍然存在。没有观察到与种族的交互作用与作为连续变量的妊娠长度有关。然而，在预测早产方面，种族和DHA：AA比率之间存在显著的交互作用(p=0.049)；仅在非裔美国人中，早产的几率随着DHA：AA的增加而降低(p=0.048)。这些数据支持炎症途径和睡眠质量在非裔美国人和欧洲裔美国女性中将不太理想的RBC PUFA状态与较短的妊娠联系起来的作用，并表明在DHA：AA比率较低的情况下，非裔美国人早产的风险更大。
Mechanistic pathways linking maternal polyunsaturated fatty acid (PUFA) status with gestational length are poorly delineated. This study examined whether inflammation and sleep quality serve as mediators, focusing on the antiinflammatory ω-3 docosahexaenoic acid (DHA; 22:6n3) and proinflammatory ω-6 arachidonic acid (AA; 20:4n6). Pregnant women (n = 135) provided a blood sample and completed the Pittsburgh Sleep Quality Index (PSQI) at 20–27 weeks gestation. Red blood cell (RBC) fatty acid levels were determined by gas chromatography and serum inflammatory markers [interleukin (IL)-6, IL-8, tumor necrosis factor-α, IL-1β, and C-reactive protein] by electrochemiluminescence using high sensitivity kits. Both higher serum IL-8 (95% CI = 0.10,3.84) and poor sleep (95% CI = 0.03,0.28) served as significant mediators linking lower DHA:AA ratios with shorter gestation. Further, a serial mediation model moving from the DHA:AA ratio → sleep → IL-8 → length of gestation was statistically significant (95% CI = 0.02, 0.79). These relationships remained after adjusting for depressive symptoms, age, BMI, income, race, and smoking. No interactions with race were observed in relation to length of gestation as a continuous variable. However, a significant interaction between race and the DHA:AA ratio in predicting preterm birth was observed (p = 0.049); among African Americans only, odds of preterm birth decreased as DHA:AA increased (p = 0.048). These data support a role for both inflammatory pathways and sleep quality in linking less optimal RBC PUFA status with shorter gestation in African American and European American women and suggest that African-Americans have greater risk for preterm birth in the context of a low DHA:AA ratio.