Intrathecal neurokinin A facilitates the spinal nociceptive flexor reflex evoked by thermal and mechanical stimuli and synergistically interacts with substance P.
Intrathecal neurokinin A facilitates the spinal nociceptive flexor reflex evoked by thermal and mechanical stimuli and synergistically interacts with substance P.
复制标题
鞘内神经激肽 A 促进由热和机械刺激引起的脊髓伤害性屈肌反射，并与 P 物质协同相互作用。
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Z. Wiesenfeld‐Hallin
中科院分区：
文献类型：
--
作者：
X. J. Xu;Z. Wiesenfeld‐Hallin
将神经肽神经激肽 A 鞘内注射，并检查其对脊髓伤害性屈肌反射的影响。这种反射是由足部的电、热或机械刺激引起的，并从同侧腿筋肌肉记录下来，鞘内注射 7 pmol 的神经激肽 A 可以显着促进反射。然而，神经激肽 A 对热刺激的促进作用明显强于电或机械刺激。此外，神经激肽A与P物质的共同给药诱导了反射的显着协同促进。有人建议，神经激肽 A 与 P 物质一样，可能与多模式 C 伤害感受器的激活有关。
The neuropeptide neurokinin A was injected intrathecally and its effect on the spinal nociceptive flexor reflex was examined. The reflex, which was evoked by electrical, thermal or mechanical stimulation of the foot and was recorded from the ipsilateral hamstring muscles, was substantially facilitated by 7 pmol intrathecally injected neurokinin A. The facilitatory effect of neurokinin A to thermal stimulation was, however, significantly stronger than to electrical or mechanical stimuli. Furthermore, co-administration of neurokinin A with substance P induced a significant synergistic facilitation of the reflex. It is suggested that neurokinin A, like substance P, may be released in association with activation of polymodal C-nociceptors.