Therapeutic Repurposing of Biguanides in Cancer.
Therapeutic Repurposing of Biguanides in Cancer.
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DOI：
10.1016/j.trecan.2021.03.001
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发表时间：
2021-08
期刊：
影响因子：
18.4
通讯作者：
Zheng B
中科院分区：
文献类型：
--
作者：
Zhao H;Swanson KD;Zheng B
双胍类药物是一类抗糖尿病药物，包括苯丙氨酸和二甲双胍，然而，由于其毒性，前者在许多国家被撤回批准。糖尿病人群和临床前实验室模型的回顾性流行病学研究结果表明，双胍类药物具有抗肿瘤活性，表明它们可用于癌症预防和治疗。然而，需要更好地了解这些双胍类化合物作为抗肿瘤药物的作用，以指导其在癌症治疗中的应用，从而激发人们对其药理学的兴趣。在这里，我们提出的证据与其抗肿瘤活性的作用机制，包括其对癌细胞中的中心碳代谢和免疫调节活性的影响，然后审查进展双胍再利用在癌症治疗和可能的重新评估phenylaldehyde作为癌症治疗剂。
Biguanides are a class of anti-diabetic drugs that includes phenformin and metformin, however, the former was withdrawn from approval in many countries due to its toxicity. Findings from retrospective epidemiological studies in diabetic populations and pre-clinical laboratory models have demonstrated that biguanides possess anti-tumor activities that suggest their repurposing for cancer prevention and treatment. However, a better understanding of how these biguanides behave as anti-tumor agents is needed to guide their improved applications in cancer therapy, spurring increased interest in their pharmacology. Here, we present evidence for proposed mechanisms of action related to their anti-tumor activity, including their effects on central carbon metabolism in cancer cells and immune-modulating activity, and then review progress on biguanide repurposing in cancer therapeutics and the possible re-evaluation of phenformin as a cancer therapeutic agent.
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影响因子：
64.8
作者：
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