Secretin-stimulated serum gastrin levels in hyperparathyroid patients from families with multiple endocrine adenomatosis type I.
Secretin-stimulated serum gastrin levels in hyperparathyroid patients from families with multiple endocrine adenomatosis type I.
复制标题
来自多发性内分泌腺瘤 I 型家族的甲状旁腺功能亢进患者中促胰液素刺激的血清胃泌素水平。
DOI：
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发表时间：
1977
影响因子：
39.2
通讯作者：
J. V. van Tongeren
中科院分区：
文献类型：
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作者：
C. Lamers;J. Buis;J. V. van Tongeren
23例甲状旁腺功能亢进患者来自6个家庭与多发性内分泌腺瘤病（MEA）I-综合征进行了测试分泌素激发。在9例病例中，这导致血清胃泌素升高，范围为298至13300 pg/ml，而其他14例患者的胃泌素最大升高为32 pg/ml。在所有9例对促胰液素有明显胃泌素反应的患者中，Zollinger-Ellison综合征的诊断是胃酸分泌过多和钙剂给药后胃泌素大量增加。这9名患者中有6名最多有轻微的餐后胃蛋白酶升高，2名有明显的肿瘤。在34名正常人、23名MEA I综合征家族的非受累成员和42名各种疾病患者中，对促胰液素的最大胃泌素反应为21 pg/ml。我们的结论是促胰液素激发有助于诊断Zollinger-Ellison综合征，特别是当基础血清胃泌素水平仅略有升高时。
Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/ml. In all nine patients with marked gastrin responses to secretin, the Zollinger-Ellison syndrome was diagnosed by gastric acid hypersecretion and large increases in gastrin after calcium administration. Six of these nine patients had, at most, minor postprandial rises in gastin and two had demonstrable tumors. In 34 normal subjects, 23 nonaffected members of families with MEA I-syndrome, and 42 patients with various diseases the maximum gastrin response to secretin was 21 pg/ml. We conclude that secretin provocation is helpful in the diagnosis of the Zollinger-Ellison syndrome, especially when basal serum gastrin levels are only slightly elevated.