Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9).
Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9).
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DOI：
10.1007/s00395-015-0463-z
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发表时间：
2015-03
影响因子：
9.5
通讯作者：
Laufs U
中科院分区：
文献类型：
--
作者：
Schulz R;Schlüter KD;Laufs U
The proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising treatment target to lower serum cholesterol, a major risk factor of cardiovascular diseases. Gain-of-function mutations of PCSK9 are associated with hypercholesterolemia and increased risk of cardiovascular events. Conversely, loss-of-function mutations cause low-plasma LDL-C levels and a reduction of cardiovascular risk without known unwanted effects on individual health. Experimental studies have revealed that PCSK9 reduces the hepatic uptake of LDL-C by increasing the endosomal and lysosomal degradation of LDL receptors (LDLR). A number of clinical studies have demonstrated that inhibition of PCSK9 alone and in addition to statins potently reduces serum LDL-C concentrations. This review summarizes the current data on the regulation of PCSK9, its molecular function in lipid homeostasis and the emerging evidence on the extra-hepatic effects of PCSK9.
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影响因子：
4.5
作者：
Cariou B;Langhi C;Le Bras M;Bortolotti M;Lê KA;Theytaz F;Le May C;Guyomarc'h-Delasalle B;Zaïr Y;Kreis R;Boesch C;Krempf M;Tappy L;Costet P
通讯作者：
Costet P
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6.5
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Jackson, Simon
DOI：
10.1073/pnas.0903849106
发表时间：
2009-06-16
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
17.1
作者：
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通讯作者：
Bentzon, Jacob F.
影响因子：
3.7
作者：
Canuel M;Sun X;Asselin MC;Paramithiotis E;Prat A;Seidah NG
通讯作者：
Seidah NG