Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reductions in both through extinction.
Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reductions in both through extinction.
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DOI：
10.1111/j.1360-0443.1986.tb00385.x
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发表时间：
1986-05
期刊：
影响因子：
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通讯作者：
A. Childress;A. Mclellan;Charles P. O'Brien
中科院分区：
文献类型：
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作者：
A. Childress;A. Mclellan;Charles P. O'Brien
在治疗社区环境中刚刚完成30天治疗计划的阿片类药物滥用者会经历强烈的药物渴望，甚至可能在暴露于药物相关刺激时经历主观戒断体征/症状。所描述的消退程序在20小时的治疗期内（住院3周）有效地几乎消除了对药物相关刺激的条件性渴望和条件性戒断体征/症状。这些研究结果进行了讨论，需要解决条件性阿片类药物相关的反应，在戒毒阿片类药物滥用者的治疗，因为这些反应可能使患者更容易复发。
Summary Abstinent opiate abusers who have just completed a 30-day treatment program in a Therapeutic Community setting experience intense drug craving and may even experience subjective withdrawal signs/symptoms when exposed to drug-related stimuli. The described extinction procedures were effective in virtually eliminating conditioned craving and conditioned withdrawal signs/symptoms to drug-related stimuli within 20 hour-long treatment sessions (a 3-week inpatient stay). These findings are discussed in terms of the need to address conditioned opiate-related responses in the treatment of abstinent opiate abusers, as these responses may make the patient more vulnerable to relapse.