Mortality in adults with self-reported asthma
Mortality in adults with self-reported asthma
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DOI：
10.1016/s0140-6736(96)90937-x
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发表时间：
1996-05-11
期刊：
影响因子：
168.9
通讯作者：
Vestbo, J
中科院分区：
文献类型：
--
作者：
Lange, P;Ulrik, CS;Vestbo, J
背景关于哮喘是否会缩短生存期的问题，已发表的工作没有给出明确的答案。我们前瞻性地分析了自报哮喘患者的总体和病因特异性死亡率。（6104名男性）20岁或以上，随机选择的一般人口的哥本哈根市，被跟踪了17 years.Findings生存在参与者与自我报告的哮喘是显着较差比非哮喘，过多的死亡率限于肺死亡率。在对年龄、受教育年限和吸烟进行统计学调整后，患有哮喘的女性比没有哮喘的女性死亡风险高1.7（95%置信区间1.3-2.2）。虽然男性死于哮喘的相对危险度（RR）略低（RR=1.5，95%CI 1.2-1.9），但性别间差异不显著。吸烟组的结果相似，与哮喘相关的死亡风险最高的是从不吸烟者（RR=2.1，95%CI 1.6-2.3）。包括一秒钟用力呼气量，%预测，在死亡率分析表明，与哮喘相关的死亡风险增加介导的主要是通过降低肺功能。解释我们得出结论，在一般人群中，自我报告的哮喘与轻微过量的死亡率，主要是呼吸系统疾病。
Background On the question of whether asthma shortens survival the published work gives no clear answer. We have prospectively analysed overall and cause-specific mortality in persons with self-reported asthma.Methods A sample of 13 540 individuals (6104 men) 20 years of age or older, randomly selected from the general population of the city of Copenhagen, was followed for 17 years.Findings Survival in participants with self-reported asthma was significantly poorer than in non-asthmatics, the excess mortality being limited to pulmonary mortality. After statistical adjustment for age, length of school education, and smoking, women with asthma had a 1.7 higher risk of dying than women without asthma (95% confidence interval 1.3-2.2). Although the relative risk (RR) of dying with asthma was sightly lower in men (RR=1.5, 95% CI 1.2-1.9) the difference between sexes was not significant. The results were similar within smoking groups and the highest risk of death associated with asthma was seen among never-smokers (RR=2.1, 95% CI 1.6-2.3). Inclusion of one-second forced expiratory volume, in % predicted, in the mortality analyses showed that the increased risk of death associated with asthma was mediated mainly through reduced lung function.Interpretation We conclude that, in the general population, self-reported asthma is associated with a slight excess of mortality, mainly from respiratory diseases.