Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.
Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.
复制标题
IGFBP5 启动子的功能多态性 (-1195T>C) 与头颈癌风险之间的关联。
DOI：
10.1002/hed.21514
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wei,Qingyi
中科院分区：
文献类型：
--
作者：
Niu,Jiangong;Huang,Yu-Jing;Wei,Sheng;Liu,Zhensheng;Wang,Li-E;Chang,Shine;Chamberlain,RobertM;El-Naggar,AdelK;Sturgis,ErichM;Wei,Qingyi
Background.To the best of our knowledge, no studies to date have evaluated roles of insulin‐like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN).Methods.A hospital‐based study of 1082 patients with SCCHN and 1120 cancer‐free controls was performed to investigate associations between 2 functional polymorphisms, ‐1195T>C and ‐709G>C, in theIGFBP5promoter region and SCCHN risk.Results.We demonstrated that the transcription factor, activator protein 1 (AP‐1), differentially bound to T or C variants at ‐1195 in the promoter to regulate theIGFBP5promoter activity and that the C variant genotypes were associated with deferential risk of late‐stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)‐unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19–4.11 for CC vs TT).Conclusion.TheIGFBP5‐1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late‐stage SCCHN. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
