Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization
Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization
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DOI：
10.1021/la803803m
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发表时间：
2009-03-03
期刊：
影响因子：
3.9
通讯作者：
Farsari, Maria
中科院分区：
文献类型：
--
作者：
Claeyssens, Frederik;Hasan, Erol A.;Farsari, Maria
以4，4 '-二乙氨基二苯甲酮为光引发剂，合成了可生物降解的三嵌段共聚物聚（ε-己内酯-co-三亚甲基乙基）-b-聚（乙二醇）-b-聚（ε-己内酯-co-三亚甲基乙基），并利用双光子聚合技术制备了三维结构。所制造的结构具有良好的质量，并且具有4微米的分辨率。初步细胞毒性试验表明，该材料不影响细胞增殖。这些研究表明，双光子聚合作为一种技术，用于制造可生物降解的组织工程支架的潜力。
Two-photon polymerization has been employed to fabricate three-dimensional structures using the biodegradable triblock copolymer poly(epsilon-caprolactone-co-trimethylenecarbonate)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylenecarbonate) with 4,4'-bis(diethylamino)benzophenone as the photoinitiator. The fabricated structures were of good quality and had four micron resolution. Initial cytotoxicity tests show that the material does not affect cell proliferation. These studies demonstrate the potential of two-photon polymerization as a technology for the fabrication of biodegradable scaffolds for tissue engineering.