Pre- and postsynaptic aspects of dopamine-mediated transmission.
Pre- and postsynaptic aspects of dopamine-mediated transmission.
复制标题
多巴胺介导的传递的突触前和突触后方面。
DOI：
10.1016/s1471-1931(00)00024-0
复制
发表时间：
2000
影响因子：
15.9
通讯作者：
Bergstrom,DA
中科院分区：
文献类型：
--
作者：
Walters,JR;Ruskin,DN;Allers,KA;Bergstrom,DA
多巴胺激动剂的应用诱导基底节核团放电频率和模式的改变，为深入了解多巴胺在基底节功能中的作用提供了线索。这些变化支持一个比早期模型中设想的更复杂、更完整的基底节网络。对基底节输出的重要功能影响包括突发性、同步性和振荡活动以及频率的改变。多巴胺受体激动剂的全身给药显著影响基底节放电频率的多秒振荡。这表明，神经元活动在比通常研究更长的时间尺度上的协调变化，在多巴胺调节的认知和运动过程中发挥了作用。
Dopamine agonist administration induces changes in firing rate and pattern in basal ganglia nuclei that provide an insight into the role of dopamine in basal ganglia function. These changes support a more complex, integrated basal ganglia network than envisioned in early models. Functionally important effects on basal ganglia output involve alterations in burstiness, synchronization and oscillatory activity, as well as rate. Multisecond oscillations in basal ganglia firing rates are markedly affected by systemic administration of dopamine-receptor agonists. This suggests that coordinated changes in neuronal activity at time scales longer than commonly investigated play a role in the cognitive and motor processes that are modulated by dopamine.