Differential absorption imaging with optical coherence tomography
Differential absorption imaging with optical coherence tomography
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DOI：
10.1364/josaa.15.002288
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发表时间：
1998-09-01
影响因子：
1.9
通讯作者：
Yung, KM
中科院分区：
文献类型：
--
作者：
Schmitt, JM;Xiang, SH;Yung, KM
后向散射截面的空间变化是当前光学相干断层扫描（OCT）应用中对比度的主要来源。我们介绍并分析了一种用于获得生物组织和其他高散射介质中吸收化合物的局部浓度的OCT图像的技术。一对发光二极管，一个在感兴趣的化合物的振动吸收带中发射，另一个在该带之外发射，被用作干涉仪输入处的光源。探测光束的微分吸收是通过对测量的干涉信号进行傅里叶变换和比率处理来确定的。该技术的能力，以区分脂质和水的夹杂物在散射材料的OCT系统，使用一对发光二极管源的中心波长为1.3 μ m和1.46 μ m的证明。(C)1998年美国光学学会。
The spatial variation of the backscattering cross section is the primary source of contrast in present applications of optical coherence tomography (OCT). We introduce and analyze a technique for obtaining OCT images of the local concentration of an absorbing compound in biological tissues and other highly scattering media. A pair of light-emitting diodes, one emitting in a vibrational absorption band of the chemical compound of interest and the other emitting just outside this band, are used as sources at the input of the interferometer. The differential absorption of the probe beam is determined by Fourier transformation and ratiometric processing of the measured interference signals. The ability of the technique to distinguish lipid and water inclusions in a scattering material is demonstrated with an OCT system that uses a pair of light-emitting-diode sources with center wavelengths of 1.3 mu m and 1.46 mu m. (C) 1998 Optical Society of America.