Age-Related Differences in Sleep Architecture and Electroencephalogram in Adolescents in the National Consortium on Alcohol and Neurodevelopment in Adolescence Sample
Age-Related Differences in Sleep Architecture and Electroencephalogram in Adolescents in the National Consortium on Alcohol and Neurodevelopment in Adolescence Sample
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DOI：
10.5665/sleep.5978
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发表时间：
2016-07-01
期刊：
影响因子：
5.6
通讯作者：
Colrain, Ian M.
中科院分区：
文献类型：
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作者：
Baker, Fiona C.;Willoughby, Adrian R.;Colrain, Ian M.
研究目的：在全国青少年酒精和神经发育协会（nanda）的一大组青少年中，考虑性别、青春期、种族和头皮地形，研究多导睡眠图和睡眠脑电图（EEG）测量的年龄相关差异。方法：经过一个适应/临床筛查夜，141名健康青少年（12-21岁，64名女孩）进行了多导睡眠图记录，从中得出睡眠分期和脑电图测量。研究地点是SRI国际人类睡眠实验室和匹兹堡大学儿科睡眠实验室。结果：年龄越大，N3睡眠比例越低，N2、N1和快速眼动睡眠（REM）的比例越高。与年龄较小的男孩相比，年龄较大的男孩在睡眠开始后更频繁地醒来和清醒，而女孩则没有这种影响。非快速眼动非快速眼动睡眠的δ (0.3-4 Hz)脑电图功率在所有电极位置上都低于青少年，枕部头皮下降的斜率更陡。高频段的脑电图功率在年龄较大的青少年中也低于年龄较小的青少年，在不同电极上的效果相同。第一个非快速眼动期的δ能量百分比在各个年龄段是相似的。与白种人相比，非洲裔美国人在各频段（δ到σ）的脑电图功率较低。最后，在模型中用青春期状态代替年龄也显示出类似的关系。结论：在这个庞大的群体中，睡眠结构和脑电图在整个青少年中存在明显的实质性差异，性别改变了一些关系。该队列的建立和随访可以研究睡眠脑电图与大脑结构的关系以及行为（如酒精和物质使用）对睡眠脑电图成熟的影响。
Study Objectives: To investigate age-related differences in polysomnographic and sleep electroencephalographic (EEG) measures, considering sex, pubertal stage, ethnicity, and scalp topography in a large group of adolescents in the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA).Methods: Following an adaptation/clinical screening night, 141 healthy adolescents (12-21 y, 64 girls) had polysomnographic recordings, from which sleep staging and EEG measures were derived. The setting was the SRI International Human Sleep Laboratory and University of Pittsburgh Pediatric Sleep Laboratory.Results: Older age was associated with a lower percentage of N3 sleep, accompanied by higher percentages of N2, N1, and rapid eye movement (REM) sleep. Older boys compared with younger boys had more frequent awakenings and wakefulness after sleep onset, effects that were absent in girls. Delta (0.3-4 Hz) EEG power in nonrapid eye movement NREM sleep was lower in older than younger adolescents at all electrode sites, with steeper slopes of decline over the occipital scalp. EEG power in higher frequency bands was also lower in older adolescents than younger adolescents, with equal effects across electrodes. Percent delta power in the first NREM period was similar across age. African Americans had lower EEG power across frequency bands (delta to sigma) compared with Caucasians. Finally, replacing age with pubertal status in the models showed similar relationships.Conclusions: Substantial differences in sleep architecture and EEG were evident across adolescence in this large group, with sex modifying some relationships. Establishment and follow-up of this cohort allows the investigation of sleep EEG-brain structural relationships and the effect of behaviors, such as alcohol and substance use, on sleep EEG maturation.