Lung vascular cell proliferation in hyperoxic pulmonary hypertension and on return to air: [3H]thymidine pulse-labeling of intimal, medial, and adventitial cells in microvessels and at the hilum.
Lung vascular cell proliferation in hyperoxic pulmonary hypertension and on return to air: [3H]thymidine pulse-labeling of intimal, medial, and adventitial cells in microvessels and at the hilum.
复制标题
高氧性肺动脉高压和返回空气时的肺血管细胞增殖：[3H]胸苷脉冲标记微血管和肺门的内膜、内侧和外膜细胞。
DOI：
10.1164/ajrccm/140.5.1471
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Farber,F
中科院分区：
文献类型：
--
作者：
Jones,R;Adler,C;Farber,F
The labeling Index (L1) of lung vascular Intimal (endothelial and precursor smooth muscle), medial (smooth muscle), and adventitial cells (fibroblasts) was established In the normal rat and In the rat with pulmonary hypertension caused by breathing high oxygen (87lMl O2 at normobarlc pressure). Cell labeling was assessed during hyperoxla (Days 1, 4, 7, 10, and 28), at the start and end of weaning hyperoxla-adapted rats to air (Days 29 and 35), and 1, 2, and 4 wk after return to breathing air after hyperoxla and weaning (Days 42, 49, and 63). Bursts of Intimal, medial, and adventitial cell proliferation different In their timing and eX1entcontribute to lung vascular wall remodeling
