Positional firing properties of postrhinal cortex neurons
Positional firing properties of postrhinal cortex neurons
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DOI：
10.1016/s0306-4522(03)00160-x
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Hafeman, DM
中科院分区：
文献类型：
--
作者：
Burwell, RD;Hafeman, DM
在清醒的行为大鼠中，海马神经元的放电通常是空间选择性的，这种细胞被称为位置细胞。类似的空间相关性也被描述为内侧内嗅和嗅周皮质中的神经元。这三个区域都接受来自后嗅皮层的感觉关联输入，而后嗅皮层又与视觉空间新皮层区域紧密相连。然而，嗅后细胞的空间选择性从未被研究过。在这里，我们报告的活动，在嗅后皮质的自由移动大鼠执行空间任务的四臂径向迷宫。数据也报告了视觉关联皮层neurons.The四臂径向迷宫被定义为多感官线索的表面上的迷宫武器（近端）和复杂的视觉线索在周围（远端）。在每个记录日，大鼠在三种条件下奔跑：基线、双线索旋转（近端+90度;远端-90度）和基线。在这项任务中，海马位置场活动是强大的，可以通过近端或远端线索控制。大多数的嗅后神经元（64%）表现出位置相关的任务，然而，这些嗅后细胞的特性是从那些先前描述的海马位置细胞有很大的不同。大多数具有放电野的嗅后细胞表现为分裂或多子野（93%）。与海马位置场，绝大多数的postrinal放电领域（84%）采用新的空间相关实验线索旋转时，但这样做既不可预测也concordanty.This位置放电相关的postrinal皮层的第一份报告。这些数据与后嗅皮层通过监测环境刺激的变化而不是编码稳定的空间线索来参与视觉空间功能的想法是一致的。因此，嗅后神经元似乎参与更高层次的知觉功能，而不是记忆功能。我们认为，嗅后神经元的反应特性代表了空间通路的早期步骤，最终在海马的特定和稳定的位置字段。(C)2003年IBRO。由爱思唯尔科技有限公司出版。保留所有权利。
Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, which, in turn, is heavily interconnected with visuospatial neocortical regions. The spatial selectivity of postrhinal cells, however, has never been examined. Here, we report the activity of neurons in postrhinal cortex of freely moving rats performing a spatial task on a four-arm radial maze. Data are also reported for visual association cortex neurons.The four-arm radial maze was defined by multisensory cues on the surfaces of the maze arms (proximal) and complex visual cues at the surround (distal). On each recording day, rats were run in three conditions: baseline, double cue rotation (proximal +90degrees; distal -90degrees), and baseline. In this task, hippocampal place field activity is robust and can be controlled by proximal or distal cues. The majority of postrhinal neurons (64%) exhibited positional correlates during performance on the task; however, characteristics of these postrhinal cells were substantially different from those previously described for hippocampal place cells. Most postrhinal cells with firing fields exhibited split or multiple subfields (93%). Unlike hippocampal place fields, the large majority of postrhinal firing fields (84%) adopted new spatial correlates when experimental cues were rotated, but did so neither predictably nor concordantly.This is the first report of positional firing correlates in the postrhinal cortex. The data are consistent with the idea that postrhinal cortex participates in visuospatial functions by monitoring changes in environmental stimuli rather than encoding stable spatial cues. Thus, postrhinal neurons appear to participate in higher-level perceptual functions rather than mnemonic functions. We propose that the response properties of postrhinal neurons represent an early step in a spatial pathway that culminates in the specific and stable place fields of the hippocampus. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.