A Chronically Implanted System for Automatic Defibrillation in Active Conscious Dogs: Experimental Model for Treatment of Sudden Death from Ventricular Fibrillation
A Chronically Implanted System for Automatic Defibrillation in Active Conscious Dogs: Experimental Model for Treatment of Sudden Death from Ventricular Fibrillation
复制标题
长期植入有意识的狗的自动除颤系统：治疗心室颤动猝死的实验模型
作者：
M. Mirowski;M. Mower;A. Langer;Julian Schreibman;M. Heilman
摘要通过一个由除颤器和交流电除颤器组成的长期植入的自动系统，在清醒的主动犬身上实现了室颤。这个密封的除颤器由钛制成，重250克，体积为145毫升。该传感器持续监测脑室电活动，并通过没有等电势节段来识别纤颤。纤颤是通过在植入的纤颤器上放置磁铁来诱发的。由此产生的晕厥与猝死的临床实体非常相似，而除颤器在心律失常发作15秒后，以30J的截断指数脉冲自动恢复正常心律。除颤器的工作状态可以用外部分析仪在体外和体内进行非侵入性测试。这一实验模型首次允许对自动植入式除颤器方法进行长期研究，以防止在各种生理病理条件下因室颤而猝死。
SUMMARY Ventricular defibrillation was achieved in active conscious dogs with a chronically implanted automatic system composed of a defibrillator and an alternating current fibrillator. The hermetically sealed defibrillator is encased in titanium, weighs 250 g and has a volume of 145 ml. The sensor continuously monitors ventricular electrical activity and recognizes fibrillation by the absence of isoelectric potential segments. Fibrillation is induced by placing a magnet over the implanted fibrillator. The resulting syncope closely resembles the clinical entity of sudden death, while the defibrillator automatically restores normal rhythm with a truncated exponential pulse of 30 J, 15 seconds after the onset of the arrhythmia. The operational status of the defibrillator can be tested in vitro and noninvasively in vivo with an external analyzer. This experimental model allows for the first time a long-term study of the automatic implantable defibrillator approach to prevent sudden death from ventricular fibrillation under a variety of physiopathologic conditions.
影响因子：
3.2
作者：
CHEN, S;THAKOR, NV;MOWER, MM
通讯作者：
MOWER, MM