High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder
High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder
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大量程序性细胞死亡 1 阳性肿瘤浸润淋巴细胞与移植后淋巴细胞增殖性疾病的早期发病相关
DOI：
10.1007/s12185-021-03129-3
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发表时间：
2021
影响因子：
2.1
通讯作者：
Ohshima Koichi
中科院分区：
文献类型：
--
作者：
Saito Hideaki;Miyoshi Hiroaki;Shibayama Hirohiko;Toda Jun;Kusakabe Shinsuke;Ichii Michiko;Fujita Jiro;Fukushima Kentaro;Maeda Tetsuo;Mizuki Masao;Oritani Kenji;Seto Masao;Yokota Takafumi;Kanakura Yuzuru;Hosen Naoki;Ohshima Koichi
移植后淋巴组织增生性疾病（PTLD）是一种危及生命的移植并发症。除了免疫功能低下患者的EB病毒再激活外，肿瘤免疫功能受损也是PTLD的一个危险因素。然而，目前尚不清楚免疫抑制性肿瘤浸润淋巴细胞（TIL）是否与PTLD的发生或预后相关。我们分析了26例PTLD患者的TIL，以阐明PD-1和FoxP 3表达的临床病理学意义，PD-1和FoxP 3分别与耗竭的T细胞和调节性T细胞（TCLs）相关。在移植后早期发生PTLD的患者中，PTLD标本中PD-1+ TIL的数量显著较高（P= 0.0040），而FoxP 3 + TIL的数量则不是（P= 0.184）。无论PD-1或FoxP 3的表达如何，总体缓解率均无差异。与FoxP 3低患者相比，FoxP 3高患者的疾病进展时间更短，尤其是在FoxP 3高的弥漫性大B细胞淋巴瘤-亚型PTLD患者中（P= 0.011），而PD-1高患者则不然。这些结果表明，T细胞耗竭可能主要与PTLD的发展，而免疫抑制THEOTH可能是占主导地位的PTLD的疾病发生后的增强进展。
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication of transplantation. In addition to reactivation of Epstein–Barr virus in immunocompromised patients, impaired tumor immunity is suggested to be a risk factor for PTLD. However, it remains unclear whether immune suppressive tumor-infiltrating lymphocytes (TILs) correlate with the occurrence or prognosis of PTLD. We analyzed TILs in 26 patients with PTLD to elucidate the clinicopathological significance of the expression of PD-1 and FoxP3, which are associated with exhausted T-cells and regulatory T-cells (Tregs), respectively. Numbers of PD-1+TILs in the PTLD specimens were significantly higher in patients who developed PTLD early after transplantation (P= 0.0040), while numbers of FoxP3+TILs were not (P= 0.184). There was no difference in overall response rate regardless of the expression of PD-1 or FoxP3. FoxP3highpatients tended to have a shorter time to progression compared with FoxP3lowpatients, especially in the case of FoxP3highpatients with diffuse large B-cell lymphoma-subtype PTLD (P= 0.011), while PD-1highpatients did not. These results suggest that T-cell exhaustion may be mainly associated with PTLD development, while immune suppression by Tregs may be dominant in enhanced progression of PTLD following disease occurrence.
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CHOP-21 用于治疗实体器官移植后的移植后淋巴增殖性疾病 (PTLD)。
影响因子：
10.1
作者：
S. Choquet;R. Trappe;V. Leblond;U. Jäger;F. Davi;S. Oertel
通讯作者：
S. Oertel
对爱泼斯坦Barr病毒的免疫反应及其对移植后淋巴增生性疾病的影响。
影响因子：
6.2
作者：
Martinez OM;Krams SM
通讯作者：
Krams SM
移植后淋巴增殖性疾病中肿瘤内叉头盒蛋白 3 的表达：临床特征和生存结果
影响因子：
6.2
作者：
D. Berglund;A. Kinch;Elin Edman;C. Backlin;G. Enblad;E. Larsson;D. Molin;K. Pauksens;C. Sundström;E. Baecklund
通讯作者：
E. Baecklund
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
45.3
作者：
Lesokhin, Alexander M.;Ansell, Stephen M.;Timmerman, John
通讯作者：
Timmerman, John