PRESSURE WAVE TRANSMISSION ALONG HUMAN AORTA - CHANGES WITH AGE AND IN ARTERIAL DEGENERATIVE DISEASE
PRESSURE WAVE TRANSMISSION ALONG HUMAN AORTA - CHANGES WITH AGE AND IN ARTERIAL DEGENERATIVE DISEASE
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DOI：
10.1161/01.res.23.4.567
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发表时间：
1968-01-01
影响因子：
20.1
通讯作者：
KROVETZ, LJ
中科院分区：
文献类型：
--
作者：
OROURKE, MF;BLAZEK, JV;KROVETZ, LJ
在诊断性导管插入术期间，记录了 39 名年龄 6 至 69 岁患者的近端主动脉、髂动脉和中间部位的压力波。在儿童中，压力波的幅度沿主动脉逐渐增加，并且在主动脉远端和髂动脉中出现明显的舒张波。轮廓的这些变化与压力波谐波的模量和相位的波动相关。随着年龄的增长，压力波在传播过程中的变化逐渐减少，并且在患有动脉退行性疾病的老年患者中，压力波的传播几乎没有变化。主动脉弓和髂动脉之间波的放大百分比（A）与年龄（x）呈负相关（A = 58.9 - 0.90x；P<0.001）。从膈肌到髂动脉的传输时间（T，毫秒）随着年龄的增长而缩短（T = 63.5 - 0.62x；P<0.001），表明动脉扩张性降低。腹主动脉和髂动脉的放大与传输时间之间的关系为A=1.04T-16.7(P<0.001)。研究结果归因于随着年龄的增长和动脉退行性疾病，外周动脉的扩张性下降导致外周反射系数下降。扩张性降低的功能影响是损害动脉系统接受脉动血流的效率，从而增加左心室的负荷。
Pressure waves were recorded in the proximal aorta, iliac artery, and intermediate sites in 39 patients, aged 6 to 69 years, during diagnostic catheterization. In children, amplitude of the pressure wave increased progressively along the aorta, and a prominent diastolic wave appeared in the distal aorta and iliac artery. These changes in contour were associated with fluctuations in modulus and phase of the pressure wave harmonics. Alterations in the pressure wave during transmission became progressively less with increasing age, and the wave was transmitted virtually unchanged in the older patients with arterial degenerative disease. Percentage amplification (A) of the wave between aortic arch and iliac artery and age (x) were inversely related (A = 58.9 - 0.90x;P<0.001). Transmission time (T, msec) from diaphragm to iliac artery shortened with age (T = 63.5 - 0.62x;P<0.001) indicating a decrease in arterial distensibility. The relationship between amplification and transmission time in the abdominal aorta and iliac artery was A = 1.04T - 16.7 (P< 0.001). Findings are attributed to a decline in peripheral reflection coefficient resulting from decreased distensibility of peripheral arteries with age and in arterial degenerative disease. The functional effects of decreased distensibility are to impair the efficiency of the arterial system in accepting pulsatile flow, and so to increase the load presented to the left ventricle.