Thyroid metastasis from nonsmall cell lung cancer.
Thyroid metastasis from nonsmall cell lung cancer.
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DOI：
10.1155/2013/208213
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发表时间：
2013
影响因子：
0.9
通讯作者：
Abdel Karim N
中科院分区：
文献类型：
--
作者：
Namad T;Wang J;Shipley R;Abdel Karim N
背景甲状腺转移是罕见的。在临床上，它们在临床研究中占甲状腺恶性肿瘤的不到4%。瞄准目的探讨肺癌甲状腺转移的临床表现及治疗方法。材料和方法。我们报告一个肺腺癌转移到甲状腺的病例。我们通过PubmMed检索回顾了1997年至2013年的类似报告。案例介绍。一名48岁女性因左上叶肺腺癌（LUL）就诊;她接受了新辅助化疗，然后接受了LUL肺叶切除术。9个月后，她出现弥漫性甲状腺肿，最初被认为是孤立性转移性病变，因为在组织病理学检查中TTF-1阳性的肺腺癌呈阳性。不幸的是，PET扫描显示额外的纵隔淋巴结肿大。结论转移性甲状腺疾病的治疗策略是基于多学科方法，其中甲状腺切除术将被考虑在一个孤立的转移性参与的情况下，但进一步的转移性检查是强制性的，以指导进一步的全身治疗与姑息性放射治疗。
Background. Thyroid metastases are rare. Clinically, they represent less than 4% of thyroid malignancy in clinical studies. Aim. To assess various presentations and therapy for patients with lung cancer metastatic in the thyroid. Materials and Methods. We report a case of metastatic adenocarcinoma of the lung to the thyroid. We reviewed similar reports through PubmMed search from 1997 until 2013. Case Presentation. A 48-year-old lady was seen in the clinic for an adenocarcinoma of left upper lobe (LUL) of the lung; she received neoadjuvant chemotherapy then LUL lobectomy. After 9 months she presented with diffuse goiter initially believed to be a solitary metastatic lesion as it was positive for adenocarcinoma of lung origin on histopathological exam with TTF-1 positivity. Unfortunately, PET scan showed additional mediastinal lymphadenopathy. Conclusion. The treatment strategy for metastatic thyroid disease is based on a multidisciplinary approach, where thyroidectomy would have been considered in case of a solitary metastatic involvement, but further metastatic workup is mandated to direct further systemic therapy versus palliative radiation therapy.