Cilia internal mechanism and metachronal coordination as the result of hydrodynamical coupling
Cilia internal mechanism and metachronal coordination as the result of hydrodynamical coupling
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DOI：
10.1073/pnas.94.12.6001
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发表时间：
1997-06-10
影响因子：
11.1
通讯作者：
Blum, JJ
中科院分区：
文献类型：
--
作者：
Gueron, S;LevitGurevich, K;Blum, JJ
我们提出了一个简单但现实的纤毛内部弯曲产生机制的模型，使用从分析单个纤毛节拍数据获得的参数，并将其整合到最近发展的动力学模型中，将结果与二维纤毛节拍的实验数据进行比较，我们证明该模型捕捉到了运动的基本特征，包括许多没有显式建立的属性，随着粘度的增加和相邻纤毛的存在而发生的节拍模式和频率变化。使用该模型，我们能够研究多纤毛结构，如纤毛排和二维纤毛阵列，当两个相邻的模型纤毛在不同的相位开始跳动时，它们在两个周期内同步，正如在实验中观察到的两个异相跳动的鞭毛靠近在一起时一样，对各种多纤毛构型的检查表明，超时模式(即相邻纤毛之间的恒定相位差的节拍)是自主演变的，这为超时现象可能是由于纤毛之间的流体动力学相互作用而发生的自组织现象提供了模型证据。
We present a simple but realistic model for the internal bend-generating mechanism of cilia, using parameters obtained from the analysis of data of the beat of a single cilium, and incorporate it into a recently developed dynamical model, Comparing the results to experimental data for two-dimensional beats, we demonstrate that the model captures the essential features of the motion, including many properties that are not built in explicitly, The beat pattern and frequency change in response to increased viscosity and the presence of neighboring cilia in a realistic fashion, Using the model, we are able to investigate multicilia configurations such as rows of cilia and two-dimensional arrays of cilia, When two adjacent model cilia start beating at different phase, they synchronize within two cycles, as observed in experiments in which two flagella beating out of phase are brought close together, Examination of various multicilia configurations shows that metachronal patterns (i.e., beats with a constant phase difference between neighboring cilia) evolve autonomously, This provides modeling evidence in support of the conjecture that metachronism may occur as a self-organized phenomenon due to hydrodynamical interactions between the cilia.