Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.
Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.
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DOI：
10.1021/ol502731p
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发表时间：
2014-11-07
期刊：
影响因子：
5.2
通讯作者：
MacMillan JB
中科院分区：
文献类型：
--
作者：
Fu P;Jamison M;La S;MacMillan JB
从链霉菌（Streptomyces sp.）化学诱导突变株中分离到三种新的氯化生物碱，它们具有由色氨酸片段和6-甲基水杨酸单元产生的酰胺骨架，并且只在突变株中产生。通过光谱分析、Marfey法和CD光谱测定了它们的结构，包括立体化学。
Inducamides A–C (1–3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey’s method, and CD spectroscopy.