Phospholipase D in endocytosis and endosomal recycling pathways.
Phospholipase D in endocytosis and endosomal recycling pathways.
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DOI:
10.1016/j.bbalip.2009.05.011
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发表时间:
2009-09
期刊:
影响因子:
--
通讯作者:
Donaldson JG
中科院分区:
文献类型:
--
作者:
Donaldson JG
The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.
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