Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response.
Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response.
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DOI：
10.1155/2011/274629
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kakkar VV
中科院分区：
文献类型：
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作者：
G HB;Rao VS;Kakkar VV
高密度脂蛋白（HDL）是血液中胆固醇的主要载体。与其他脂蛋白不同，HDL的生理功能以有利的方式影响心血管系统，除非HDL被病理修饰。高密度脂蛋白的心脏保护机制主要是基于逆向胆固醇转运，但高密度脂蛋白的抗炎和抗氧化作用已引起人们的兴趣。HDL的后一种活性在许多与炎症相关的病理状态下受到损害。此外，异常的高密度脂蛋白可以促进炎症，导致氧化损伤。在本文中，我们讨论了HDL的功能异质性，炎症状态下这些颗粒的改变如何导致与动脉粥样硬化相关的抗氧化活性和逆向胆固醇运输的丧失，以及预测其功能的检测需求。
High-density lipoprotein (HDL) is a major carrier of cholesterol in the blood. Unlike other lipoproteins, physiological functions of HDL influence the cardiovascular system in favorable ways except when HDL is modified pathologically. The cardioprotective mechanism of HDL is mainly based on reverse cholesterol transport, but there has been an emerging interest in the anti-inflammatory and antioxidant roles of HDL. These latter activities of HDL are compromised in many pathological states associated with inflammation. Further, abnormal HDL can become proinflammatory contributing to oxidative damage. In this paper, we discuss the functional heterogeneity of HDL, how alterations in these particles in inflammatory states result in loss of both antioxidant activity and reverse cholesterol transport in relation to atherosclerosis, and the need for assays to predict its functionality.