The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?
The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?
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DOI：
10.1177/2470547021996006
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Harpaz-Rotem I
中科院分区：
文献类型：
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作者：
Seidemann R;Duek O;Jia R;Levy I;Harpaz-Rotem I
创伤后应激障碍(PTSD)是一种非常普遍的疾病，也是一种非常虚弱的疾病。尽管快感缺乏是这种障碍的一个重要组成部分，但创伤后应激障碍和奖赏功能之间的关系仍未得到充分研究。到目前为止，大多数关于创伤后应激障碍的研究都集中在恐惧：恐惧的学习、维持和消亡。在这里，我们回顾相关文献--包括临床观察、自我报告数据、神经影像研究和动物研究--以检验创伤后应激障碍对奖赏系统的潜在影响。我们目前对创伤如何影响奖励系统缺乏足够的洞察力，这可能是临床进展的障碍之一。目前的综述强调有必要进一步研究创伤暴露和奖励系统之间的复杂关系，以加深我们对创伤后应激障碍行为学的理解。
Post-traumatic stress disorder (PTSD) is a highly prevalent disorder and a highly debilitating condition. Although anhedonia is an important construct of the disorder, the relationship between PTSD and reward functioning is still under-researched. To date, the majority of research on PTSD has focused on fear: fear learning, maintenance, and extinction. Here we review the relevant literature—including clinical observations, self-report data, neuroimaging research, and animal studies—in order to examine the potential effects of post-traumatic stress disorder on the reward system. Our current lack of sufficient insight into how trauma affects the reward system is one possible hindrance to clinical progress. The current review highlights the need for further investigation into the complex relationship between exposure to trauma and the reward system to further our understandings of the ethology of PTSD.