[Incidence trend and change in the age distribution of female breast cancer in cancer registration areas of China from 2000 to 2014].
[Incidence trend and change in the age distribution of female breast cancer in cancer registration areas of China from 2000 to 2014].
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DOI：
10.3760/cma.j.issn.0253-9624.2018.06.003
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发表时间：
2018-06-06
影响因子：
--
通讯作者：
He, J
中科院分区：
文献类型：
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作者：
Sun, K X;Zheng, R S;He, J
目的：了解2000 - 2014年中国癌症登记区女性乳腺癌发病趋势及年龄分布变化。方法：选取2000 - 2014年全国22个具有连续监测数据的癌症登记处。根据数据质量控制标准对所有数据集进行检查和评估，并纳入分析。癌症登记涵盖675 954 193人年，其中男性为342 010 930人年，女性为333 943 263人年。提取女性乳腺癌病例（国际疾病分类-10（th）修订版：C50）。计算粗发病率（CR）、中国标准人群年龄标准化发病率（ASIRC）、年变化率（APC）、粗发病年龄和调整后的平均发病年龄。按地区和年龄组分层计算发病率。结果：女性乳腺癌发病率由2000年的31.90/10万显著上升至2014年的63.30/10万。2000 ~ 2008年发病率迅速上升（CR: APC=6.5%, 95%CI: 5.3% ~ 7.8%; ASIRC: APC=4.6%, 95%CI: 3.6% ~ 5.7%）。2008-2014年，其增幅有所放缓（CR: APC=3.2%, 95%CI: 1.4%-5.1%; ASIRC: APC=1.4%, 95%CI:-0.1%-2.9%）。粗平均发病年龄由2000年的54.4岁上升至2014年的57.0岁。2014年调整后的平均发病年龄保持在54.3岁左右。所有登记区的粗平均发病年龄均随时间显著增加(β =0.192， P
Objective: To estimate the incidence trend and change in the age distribution of female breast cancer in cancer registry areas in China from 2000 to 2014. Methods: 22 cancer registries in China with continuous monitoring data from 2000 to 2014 were selected. All datasets were checked and evaluated based on data quality control criteria and were included in the analysis. The cancer registries covered 675 954 193 person-years, including 342 010 930 person-years of male and 333 943 263 person-years of female. Female breast cancer cases (International Classification of Diseases-10(th) Revision: C50) were extracted. Crude incidence rate (CR), age-standardized incidence rate by Chinese standard population(ASIRC), annual percent change (APC), crude and adjusted mean age at onset were calculated. Incidence rates stratified by regions and age groups were calculated. Results: Female breast cancer incidence rate significantly increased from 31.90/100 000 in 2000 to 63.30/100 000 in 2014. Incidence rate increased rapidly from 2000 to 2008 (CR: APC=6.5%, 95%CI: 5.3%-7.8%; ASIRC: APC=4.6%, 95%CI: 3.6%-5.7%). Its increment slowed down from 2008-2014 (CR: APC=3.2%, 95%CI: 1.4%-5.1%; ASIRC: APC=1.4%, 95%CI:-0.1%-2.9%). The crude mean age at onset increased from 54.4 in 2000 to 57.0 in 2014. Adjusted mean age at onset remained around 54.3 in 2014. Crude mean age at onset increased significantly over time in all registry areas (beta=0.192, P