Epigenetics in AML
Epigenetics in AML
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DOI：
10.1016/j.beha.2010.09.017
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发表时间：
2010-12-01
影响因子：
2.1
通讯作者：
Melnick, Ari M.
中科院分区：
文献类型：
--
作者：
Melnick, Ari M.
表观遗传调控影响基因表达，最近的研究表明，异常的DNA甲基化模式可能在白血病发生中起作用。所有白血病都表现出异常的胞嘧啶甲基化分布，在急性髓性白血病（AML）中以特异性和明显的特征分布最为明显。这些特征反映了白血病的机制，具有临床和预后意义。与遗传性病变相比，表观遗传性病变似乎更频繁和复发。(C) 2010年Elsevier Ltd.出版。
Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. All leukemias display aberrant distribution of cytosine methylation, which is most notably distributed in specific and distinct signatures in acute myeloid leukemia (AML). These signatures reflect leukemic mechanisms and have clinical and prognostic significance. Compared with genetic lesions in AML, epigenetic lesions appear to be more frequent and recurrent. (C) 2010 Published by Elsevier Ltd.