First identification of azaspiracid and spirolides in Mesodesma donacium and Mulinia edulis from Northern Chile
First identification of azaspiracid and spirolides in Mesodesma donacium and Mulinia edulis from Northern Chile
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DOI：
10.1016/j.toxicon.2009.07.014
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发表时间：
2010-02-01
期刊：
影响因子：
2.8
通讯作者：
Blanco, Juan
中科院分区：
文献类型：
--
作者：
Alvarez, Gonzalo;Uribe, Eduardo;Blanco, Juan
为了评估人类食用与科金博湾（智利）两种重要的商业双壳贝类-马查（Mesodesma donacium）和蛤蜊（Mulinia edulis）-积累亲脂性毒素有关的风险，2008年3月至9月对这些物种进行了监测。采用液相色谱-质谱联用技术（LC-MS）对样品中的冈田酸、甲藻毒素、果胶毒素、azaspiracids、耶索毒素和螺内酯进行检测。在这两个物种中发现低水平的Azaspiracid-1和13-去甲基C螺内酯。在整个监测期间的不同日期检测到毒素，在某些情况下，在同一样品中检测到两种毒素。在所有情况下，毒素的浓度均低于所用技术的定量限，因此这些检测结果仅表明存在潜在风险。这是关于智利出现这几类毒素的第一份报告，并表明有必要对这些物质进行例行监测，以保证公共卫生和贝类出口。(C)2009爱思唯尔有限公司保留所有权利。
In an attempt to evaluate the risk for human consumption associated to the accumulation of lipophilic toxins by two commercially important bivalves: macha (Mesodesma donacium) and clam (Mulinia edulis) in Coquimbo Bay (Chile), monitoring of these species was carried out from March to September 2008. The samples were analyzed by liquid chromatography-mass spectrometry (LC-MS) to detect okadaic acid, dinophysistoxins, pectenotoxins, azaspiracids, yessotoxins and spirolides. Low levels of Azaspiracid-1 and 13-desmethyl C spirolide were found in both species. The toxins were detected at different dates throughout the monitoring period and in some cases both toxins were detected in the same sample. In all cases, the concentration of the toxins was below the limit of quantification of the technique used and therefore these detections are only indicative of a potential risk. This is the first report of the occurrence of these groups of toxins in Chile and suggests that it is necessary to monitor routinely these substances to warrant public health and shellfish exportations. (C) 2009 Elsevier Ltd. All rights reserved.