CONTRIBUTE TO THE REDUCED WEIGHT-GAIN FOLLOWING CHRONIC VENTROMEDIAL HYPOTHALAMIC-STIMULATION
CONTRIBUTE TO THE REDUCED WEIGHT-GAIN FOLLOWING CHRONIC VENTROMEDIAL HYPOTHALAMIC-STIMULATION
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DOI：
10.1016/0166-4328(94)90021-3
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发表时间：
1994-06-30
影响因子：
2.7
通讯作者：
SCHINDLER, D
中科院分区：
文献类型：
--
作者：
BIELAJEW, C;STENGER, J;SCHINDLER, D
这份报告跟进我们早期的发现，慢性腹内侧下丘脑刺激引起体重增加的抑制。在这项研究中，我们研究了刺激诱导的活动和棕色脂肪组织产热减少体重增加后，每隔一天提供的腹内侧下丘脑和邻近地区的三个会议的低水平刺激的贡献。在刺激试验期间，活动水平按二分量表进行排名。随后再监测4周的体重增加和食物摄入量，然后评估60秒刺激试验对核心和肩胛间棕色脂肪组织温度的影响。最高的活动与腹内侧下丘脑的网站，这一因素有助于显着的差异，体重增加和食物摄入量所造成的腹内侧下丘脑和其他地区的刺激。这些差异在随访期间基本消失。几乎没有例外，没有一个部位引起棕色脂肪组织的温度变化。正如在急性工作中所证明的，刺激诱导的活动的贡献必须与腹内侧下丘脑刺激引起的代谢变化分离。
This report follows up our earlier finding that chronic ventromedial hypothalamic stimulation caused an inhibition of weight gain. In this study we examined the contribution of stimulation-induced activity and brown adipose tissue thermogenesis to the reduced weight gain following three sessions of low-level stimulation delivered every other day to the ventromedial hypothalamus and adjacent areas. During stimulation trials, activity level was ranked on a dichotomous scale. Weight gain and food intake were subsequently monitored for an additional 4 weeks, after which the effects of a 60-s stimulation trial on the temperature of core and interscapular brown adipose tissue were evaluated. The highest activity was associated with the ventromedial hypothalamic sites and this factor contributed significantly to the difference in weight gain and food intake resulting from stimulation of the ventromedial hypothalamus and other areas. These differences largely disappeared during the follow-up period. With little exception, none of the sites elicited temperature changes in brown adipose tissue. As demonstrated in acute work, the contribution of stimulation-induced activity must be dissociated from the metabolic changes that occur in response to ventromedial hypothalmic stimulation.