Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections.
Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections.
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DOI：
10.1155/2015/640540
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发表时间：
2015
影响因子：
4.6
通讯作者：
Luberto C
中科院分区：
文献类型：
--
作者：
Bryan AM;Del Poeta M;Luberto C
真菌感染对日益增加的免疫功能低下人群构成重大风险。吞噬细胞在真菌病原体的免疫防御中发挥重要作用，但宿主与真菌之间的相互作用仍不清楚。鞘脂已被证明在许多细胞功能中发挥重要作用，包括吞噬细胞的功能。在这篇综述中，我们讨论了与鞘脂在巨噬细胞和中性粒细胞功能中的重要性以及巨噬细胞和中性粒细胞在最常见类型的真菌感染中的作用有关的主要发现，以及将这三个概念联系起来以显示鞘脂信号在真菌感染免疫反应中的重要性的研究。
Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function and the role of macrophages and neutrophils in the most common types of fungal infections, as well as studies that have linked these three concepts to show the importance of sphingolipid signaling in immune response to fungal infections.