The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan.
The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan.
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全国对日本的调查中，肝细胞癌复杂肝硬化的病因过渡。
DOI：
10.1007/s00535-020-01748-x
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发表时间：
2021-03
影响因子：
6.3
通讯作者：
Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
中科院分区：
文献类型：
--
作者：
Enomoto H;Ueno Y;Hiasa Y;Nishikawa H;Hige S;Takikawa Y;Taniai M;Ishikawa T;Yasui K;Takaki A;Takaguchi K;Ido A;Kurosaki M;Kanto T;Nishiguchi S;Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
我们最近报道了基于全国调查数据的肝硬化（LC）病因的现实变化，并评估了LC合并肝细胞癌（HCC）的病因。来自68家机构的55名参与者提供了23，637例HCC并发LC患者的数据。评估病因学的变化趋势。我们进一步分析了29家医院的数据，这些医院提供了2008年至2016年（N = 9362）每年新发现的HCC并发LC患者数量，无任何缺失年份，并评估了新发现的HCC并发LC病例的真实的数量的变化。在整个队列中，丙型肝炎病毒（HCV）感染（60.3%）和B肝炎病毒（HBV）感染（12.9%）分别是日本HCC并发LC的主要和第三常见原因。HCV感染被认为是日本的主要原因。病毒性肝炎相关的HCC的发生率从85.3%下降到64.4%。在非病毒病因中，观察到非酒精性脂肪性肝炎（NASH）相关HCC（从1.5%至7.2%）和酒精性肝病（ALD）相关HCC（从8.5%至18.6%）显著增加。关于新诊断患者的真实的数量，病毒性肝炎相关HCC患者的数量减少，而非病毒性HCC，特别是NASH相关HCC患者的数量增加。在日本，病毒性肝炎仍然是HCC的主要原因。然而，病毒性肝炎相关的HCC，特别是HCV相关的HCC的减少高度有助于病因学的变化。此外，非病毒性HCC，特别是NASH相关HCC的发病率增加，与日本HCC合并LC病因的变化有关。本文的在线版本（10.1007/s 00535 -020-01748-x）包含补充材料，可供授权用户使用。
We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC). Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The changing trends in etiologies were assessed. We further analyzed the data from 29 hospitals that provided the annual number of newly identified HCC-complicated LC patients from 2008 to 2016 (N = 9362) without any missing years and assessed the transition in the real number of newly identified HCC-complicated LC cases. In the overall cohort, hepatitis C virus (HCV) infection (60.3%) and hepatitis B virus (HBV) infection (12.9%) were the leading and third-most common causes of HCC-complicated LC in Japan, respectively. HCV infection was found to be the leading cause throughout Japan. The rate of viral hepatitis-related HCC decreased from 85.3 to 64.4%. Among non-viral etiologies, notable increases were observed in nonalcoholic steatohepatitis (NASH)-related HCC (from 1.5 to 7.2%) and alcoholic liver disease (ALD)-related HCC (from 8.5 to 18.6%). Regarding the real number of newly diagnosed patients, the number of patients with viral hepatitis-related HCC decreased, while the number of patients with non-viral HCC, particularly NASH-related HCC, increased. Viral hepatitis has remained the main cause of HCC in Japan. However, the decrease in viral hepatitis-related HCC, particularly HCV-related HCC highly contributed to the etiological changes. In addition, the increased incidence of non-viral HCC, particularly NASH-related HCC, was involved in the changing etiologies of HCC-complicated LC in Japan. The online version of this article (10.1007/s00535-020-01748-x) contains supplementary material, which is available to authorized users.
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影响因子：
6.3
作者：
Tokushige, Katsutoshi;Hashimoto, Etsuko;Higuchi, Susumu
通讯作者：
Higuchi, Susumu
DOI：
10.1111/hepr.12378
发表时间：
2015-01
期刊：
Hepatology research : the official journal of the Japan Society of Hepatology
影响因子：
--
作者：
Osaki Y;Nishikawa H
通讯作者：
Nishikawa H
影响因子：
4.2
作者：
Mashiba，Toshie;Joko，Kouji;Izumi，Namiki
通讯作者：
Izumi，Namiki
影响因子：
6.3
作者：
Enomoto, Hirayuki;Ueno, Yoshiyuki;Nishiguchi, Shuhei
通讯作者：
Nishiguchi, Shuhei
影响因子：
4.2
作者：
Ando, Ryoichi;Asahina, Yasuhiro;Yotsuyanagi, Hiroshi
通讯作者：
Yotsuyanagi, Hiroshi