Hydrogen and halogen bonds in drug-drug cocrystals of X-uracil (X = F, I) and lamivudine: extended quadruplex and layered assemblies
Hydrogen and halogen bonds in drug-drug cocrystals of X-uracil (X = F, I) and lamivudine: extended quadruplex and layered assemblies
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DOI：
10.1080/10610278.2022.2163644
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发表时间：
2021-12
影响因子：
3.3
通讯作者：
Chang-Zhi Li;E. Keene;Celymar Ortiz-de León;Leonard R. MacGillivray
中科院分区：
文献类型：
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作者：
Chang-Zhi Li;E. Keene;Celymar Ortiz-de León;Leonard R. MacGillivray
摘要我们报道了细胞毒性化疗药物5-氟（5 FU）/碘脲嘧啶（5IU）和抗逆转录病毒药物拉米夫定（3 TC）的药物-药物共晶体。共晶2（5 FU）·（3 TC）通过氢键维持以产生三维（3D）网络，而共晶（5IU）·（3 TC）中的卤键有效地破坏氢键以形成层状组装体。图形摘要
ABSTRACT We report drug-drug cocrystals of the cytotoxic chemotherapy drugs 5-fluoro (5FU)/iodouracil (5IU) and the antiretroviral lamivudine (3TC). The cocrystal 2(5FU)·(3TC) is sustained by hydrogen bonds to generate a three-dimensional (3D) network while halogen bonds in the cocrystal (5IU)·(3TC) effectively disrupt hydrogen bonds to form layered assemblies. Graphical abstract