Modulation of the flavin-containing monooxygenase in guinea pigs by ascorbic acid and food restriction.
Modulation of the flavin-containing monooxygenase in guinea pigs by ascorbic acid and food restriction.
复制标题
抗坏血酸和食物限制对豚鼠含黄素单加氧酶的调节。
DOI：
10.1093/jn/117.2.286
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
V. Zannoni
中科院分区：
文献类型：
--
作者：
J. Brodfuehrer;V. Zannoni
研究了通过改变抗坏血酸和食物摄入量对含黄素单加氧酶（FMO）的调节。饲喂限制量饮食的缺乏抗坏血酸的豚鼠中，FMO 的肝脏活性导致体重减轻 10-15%，是饲喂限制量充足饮食的豚鼠的 17%。在限制食物的方案中补充抗坏血酸的豚鼠中，FMO 肝活性是随意喂养充足饮食的豚鼠的 176%。这种活动的增加与压力无关。抗坏血酸缺乏和食物摄入减少相结合，改变了这一重要药物代谢酶系统的活性，可能会改变多种药物和环境化学物质的代谢速率。
Modulation of the flavin-containing monooxygenase (FMO) by varying the ascorbic acid and food intake was investigated. Hepatic activity of the FMO in ascorbic acid-deficient guinea pigs fed a restricted amount of diet which resulted in a 10-15% body weight loss, was 17% of that in animals fed restricted amounts of the adequate diet. FMO hepatic activity in ascorbic acid-supplemented guinea pigs on a food-restricted regimen was 176% of that found in animals fed the adequate diet ad libitum. This increase in activity was not related to stress. Alteration in the activity of this important drug-metabolizing enzyme system by a combination of ascorbic acid deficiency and reduced food intake could potentially alter the rate of metabolism of a great variety of pharmaceutical drugs and environmental chemicals.