The genetic and molecular organization of the dense cluster of functionally related, vital genes in the DOPA decarboxylase region of the Drosophila melanogaster genome.
The genetic and molecular organization of the dense cluster of functionally related, vital genes in the DOPA decarboxylase region of the Drosophila melanogaster genome.
复制标题
果蝇基因组多巴脱羧酶区域中功能相关的重要基因密集簇的遗传和分子组织。
DOI：
10.1007/978-3-540-47783-9_7
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发表时间：
1987
影响因子：
--
通讯作者：
Wright,TR
中科院分区：
文献类型：
--
作者：
Wright,TR
基因组中存在的功能相关基因簇表现出一些序列同源性，通常被解释为由于先前发生了适当数量的基因复制事件以及随后不同数量的复制基因的分化进化。一簇基因的分化程度可能取决于许多不同的因素，如复制事件发生在系统发育的早期，剂量考虑，即对大量或多或少相同的蛋白质或RNA分子的需求，以及维持相似但新的功能的选择压力。此外，复制基因簇的存在，其中一些可能包括假基因，可能是由于随机的机会，复制对生物体没有选择的优势或劣势（Loomis和Gilpin 1986）。另一方面，基因组中可能维持着同源但具有相关功能的基因簇，以方便基因在时间和空间上的协调或顺序调控。
The presence in the genome of clusters of functionally related genes exhibiting some sequence homology with each other has generally been interpreted to be due to the previous occurrence of the appropriate number of gene duplication events along with varying amounts of subsequent, divergent evolution of the duplicated genes. Just how far the genes within a cluster have diverged probably has been dependent on a number of different factors such as how early in the phylogeny the duplication event occurred, dosage considerations, i.e., the need for large amounts of more or less identical proteins or RNA molecules, and selective pressures to maintain similar, but new functions. Furthermore, the existence of clusters of duplicated genes, some of which may include pseudogenes, may be due to random chance, with the duplications providing no selective advantage or disadvantage to the organism (Loomis and Gilpin 1986). On the other hand, clusters of homologous, but diverged genes with related functions may be maintained in the genome to facilitate the coordinate or sequential regulation of genes in time and space.