Synthesis and Insecticidal Activity of Enzyme-Triggered Functionalized Hollow Mesoporous Silica for Controlled Release
Synthesis and Insecticidal Activity of Enzyme-Triggered Functionalized Hollow Mesoporous Silica for Controlled Release
复制标题
酶触发功能化中空介孔控释二氧化硅的合成及杀虫活性
DOI：
10.1021/acs.jafc.7b02560
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发表时间：
2017-09-13
影响因子：
6.1
通讯作者：
Li, Jianhong
中科院分区：
文献类型：
--
作者：
Kaziem, Amir E.;Gao, Yunhao;Li, Jianhong
在本研究中，酶响应控释制剂（CRF）的制造。CRF通过使用α-环糊精将机械互锁分子锚定到中空介孔二氧化硅（HMS）的表面孔边缘上来实现。采用傅里叶变换红外光谱、扫描电子显微镜、透射电子显微镜和热重分析对CRF进行了表征。结果表明，该复合材料对氯虫苯甲酰胺（42%w/w）具有非凡的负载能力，并能有效保护氯虫苯甲酰胺在高温和紫外线照射下不被降解。CRF已被证明是酶敏感的。外源性α-淀粉酶的引入可显著加快氯虫苯甲酰胺的释放速率。以小菜蛾为靶标昆虫，通过定期取样饲养试验，评价了控释肥的持效性。结果表明，在各浓度下，小菜蛾幼虫14 d的死亡率均显著高于Coragen，说明控释肥具有显著的持效性。
In the present study, enzymatic responsive controlled release formulations (CRFs) were fabricated. The CRFs were achieved by anchoring mechanically interlocked molecules using alpha-cyclodextrin onto the surface pore rims of hollow mesoporous silica (HMS). The CRFs were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and thermogravimetric analysis. The results showed that the CRFs had extraordinary loading ability for chlorantraniliprole (42% w/w) and could effectively preserve chlorantraniliprole against degradation under thermal conditions and UV radiation. The CRFs have been proven to be enzyme-sensitive. The release ratio of chlorantraniliprole from CRFs can be accelerated observably when external a-amylase was introduced. The persistence of CRFs was evaluated by regular sampling feeding experiment using Plutella xylostella as the target insect. The results showed that the larval mortality of P. xylostella was much higher than that of Coragen under all concentrations after 14 days, which proved that CRFs had remarkable persistence.