Prevalence of potential drug-drug interactions in Swedish pediatric outpatients
Prevalence of potential drug-drug interactions in Swedish pediatric outpatients
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DOI：
10.1371/journal.pone.0220685
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发表时间：
2019-08-05
期刊：
影响因子：
3.7
通讯作者：
Mannheimer, Buster
中科院分区：
文献类型：
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作者：
Holm, Johan;Eiermann, Birgit;Mannheimer, Buster
目的了解瑞典儿科门诊处方药物中潜在药物相互作用（ddi）的发生情况。方法采用横断面研究方法，对0-17岁儿童在药店配发的国家处方药登记数据进行研究。研究时间为2010年1月1日至4月30日。药品调剂数据链接到DDI数据库SFINX。研究了潜在相互作用的发生率和频率，并确定了相互作用中通常涉及的药物。研究重点是临床相关的潜在相互作用，D类（应避免）和C类（可以处理，例如通过剂量调整）。结果瑞典0 ~ 17岁儿童中，12% （n = 231 078）的儿童至少有两种配药。在这组患者中，0.14%有潜在的d相互作用，1.3%有潜在的c相互作用。可能导致效果降低的D-和c -相互作用的数量分别为181个（52%）和1224个（32%）。10种最常见的药物分别参与了所有潜在D-和c -相互作用的78%和65%。此外，80%的D-和58%的c -相互作用分别发生在12至17岁的患者中。结论：我们确定了有限数量的药物，这些药物代表了大多数潜在的相互作用。可能导致治疗效果降低的相互作用约占d相互作用的一半，占c相互作用的三分之一。在年龄较大的儿童中，潜在互动的频率更高。结果可能有助于提高儿科门诊患者对重要的潜在药物相互作用的认识。
PurposeTo describe the occurrence of potential drug-drug interactions (DDIs) in prescribed drugs, dispensed to pediatric outpatients in Sweden.MethodsA cross sectional study was conducted based on data from a national register of prescribed drugs, dispensed at pharmacies, to children 0-17 years old. The study period was January 1 to April 30, 2010. Drug dispensing data was linked to the DDI database SFINX. Prevalence and frequencies of potential interactions were investigated, and drugs commonly involved in interactions were identified. The study focused on clinically relevant potential interactions, class D (should be avoided), and class C (can be handled, e.g. by dose adjustment).ResultsIn the Swedish pediatric population, 0 to 17 years of age, 12% (n = 231 078) of children had at least two dispensed drugs. In this group of patients, 0.14% had potential D-interactions and 1,3% had potential C-interactions. The number of D- and C-interactions that may lead to reduced effects were 181 (52%), and 1224 (32%) respectively. The ten most frequent drugs were involved in 78% and 65% of all potential D-, and C-interactions respectively. Furthermore, 80%, and 58% of the D-, and C-interactions respectively occurred in patients aged 12 to 17.ConclusionsWe identified a limited number of drugs that were represented in the majority of potential interactions. Interactions that can lead to a reduced treatment effect constituted approximately half of D-interactions, and a third of C-interactions. The frequency of potential interactions was higher in older children. The results may contribute to increased prescriber awareness of important potential drug interactions among pediatric outpatients.