Immobilization of Red Fox (Vulpes vulpes) with Medetomidine-Ketamine or Medetomidine-Midazolam and Antagonism with Atipamezole
Immobilization of Red Fox (Vulpes vulpes) with Medetomidine-Ketamine or Medetomidine-Midazolam and Antagonism with Atipamezole
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美托咪定-氯胺酮或美托咪定-咪达唑仑对红狐（Vulpes vulpes）的固定以及阿替美唑的拮抗作用
DOI：
10.1638/2009-0028.1
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
A. Epstein
中科院分区：
文献类型：
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作者：
Y. Shilo;R. Lapid;R. King;T. Bdolah;A. Epstein
本文用美托咪定（0.076 ± 0.017 mg/kg）+氯胺酮（2.1 ± 0.5 mg/kg; MK，n = 16）、美托咪定（0.057 ± 0.008 mg/kg）+小剂量咪达唑仑（0.6 ± 0.1 mg/kg; MM-0.5，n = 10）或美托咪定（0.067 ± 0.012 mg/kg）+大剂量咪达唑仑（1.3 ± 0.2 mg/kg; MM-1，n = 6）三种组合中的一种通过肌肉注射固定32只自由放养的赤狐（Vulpesvulpes）。 注射记录诱导和恢复时间。测量脉搏、呼吸频率、体温、收缩压和舒张压以及血氧饱和度。观察麻醉深度指标。MM-0.5组和MM-1组的诱导时间存在显著差异，分别为8.1 ± 2.1 min和5.0 ± 1.7 min。MK诱导时间为6.9 ± 2.5 min，与其他两组无显著差异。所有组合提供了有效的固定至少20-25分钟。在固定期间，有显着差异直肠温度，这是在MK组较高;和血压，这是在MM-1组较高。阿替美唑5 mg/1 mg美托咪定给药后，两组间的恢复时间存在显著差异; MK狐狸在3.9 ± 1.7 min内站立，MM-0.5狐狸在10.6 ± 4.5 min内站立，MM-1狐狸在10.2 ± 3.4 min内站立。所有组合均未导致粗略或延长的恢复。主观上，MM组比MK组恢复更平稳，共济失调更少。总之，作者建议使用0.07 mg/kg美托咪定联合0.8 mg/kg咪达唑仑或2 mg/kg氯胺酮固定自由放养的红狐。在制动期间，建议监测体温和氧合。
Abstract Thirty-two free-ranging red foxes (Vulpes vulpes) were immobilized with one of three combinations: medetomidine (0.076 ± 0.017 mg/kg) and ketamine (2.1 ± 0.5 mg/kg; MK, n = 16), medetomidine (0.057 ± 0.008 mg/kg) and low-dose midazolam (0.6 ± 0.1 mg/kg; MM-0.5, n = 10), or medetomidine (0.067 ± 0.012 mg/kg) and high-dose midazolam (1.3 ± 0.2 mg/kg; MM-1, n = 6) by i.m. injection. Induction and recovery times were recorded. Pulse, respiratory rate, body temperature, systolic and diastolic blood pressure, and oxygen saturation were measured. Anesthesia depth indicators were observed. There was a significant difference between the MM-0.5 and the MM-1 groups regarding induction time, 8.1 ± 2.1 min and 5.0 ± 1.7 min, respectively. The MK induction time was 6.9 ± 2.5 min, which was not significantly different from the other two groups. All combinations provided effective immobilization for at least 20–25 min. During immobilization, there were significant differences regarding rectal temperature, which was higher in the MK group; and blood pressure, which was higher in the MM-1 group. After administration of atipamezole at 5 mg per 1 mg medetomidine given, there was a significant difference between the groups in recovery time; MK foxes were standing within 3.9 ± 1.7 min, MM-0.5 foxes within 10.6 ± 4.5 min, and MM-1 foxes within 10.2 ± 3.4 min. None of the combinations caused rough or prolonged recoveries. Subjectively, the MM groups had smoother and less ataxic recoveries than the MK group. In conclusion, the authors recommend the use of medetomidine at 0.07 mg/kg in combination with midazolam at 0.8 mg/kg or ketamine at 2 mg/kg for the immobilization of free-ranging red foxes. During immobilization, monitoring of body temperature and oxygenation is recommended.
犬美托咪定、美托咪定-咪达唑仑和美托咪定-咪达唑仑-布托啡诺的定量脑电图
DOI：
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发表时间：
2002
期刊：
Journal of Veterinary Medicine, Series A 49・4
影响因子：
--
作者：
Tamas Ambrisko;T.D.Ambrisko;K.Tsujino;Tamas Ambrisko;Tamas Ambrisko;Tamas Ambrisko;Yoshiaki Hikasa;Kazuhito Itamoto
通讯作者：
Kazuhito Itamoto