Atherosclerosis in apoE knockout mice infected with multiple pathogens
Atherosclerosis in apoE knockout mice infected with multiple pathogens
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DOI：
10.1086/317938
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发表时间：
2001-01-15
影响因子：
6.4
通讯作者：
Epstein, SE
中科院分区：
文献类型：
--
作者：
Burnett, MS;Gaydos, CA;Epstein, SE
巨细胞病毒（CMV）和肺炎衣原体（CP）可能导致动脉粥样硬化。鼠 CMV (MCMV) 和 CP 会增加 apoE 敲除小鼠的病变大小。在这项研究中，apoE 基因敲除小鼠感染了 MCMV 和 CP，以确定多种病原体感染是否会比单独一种病原体更大程度地增加病变大小，以及 MCMV 感染是否会改变血清细胞因子水平，从而增加病变发展。一组小鼠在 2 周龄时接受 MCMV，随后在 6 周龄和 8 周龄时接受 2 剂 CP。其他组仅接受 MCMV 或 CP。在16周龄时处死动物以确定损伤面积。单独感染 MCMV、单独感染 CP 以及同时感染 MCMV 和 CP 可使病变大小增加 84%（P
Cytomegalovirus (CMV) and Chlamydia pneumoniae (CP) possibly contribute to atherosclerosis. Murine CMV (MCMV) and CP increase lesion size in apoE knockout mice. In this study, apoE knockout mice were infected with MCMV and CP to determine whether infection with multiple pathogens increases lesion size to a greater extent than either pathogen alone and whether infection with MCMV changes serum cytokine levels in a manner that could increase lesion development. One group of mice received MCMV at 2 weeks of age, followed by 2 doses of CP at 6 and 8 weeks of age. Additional groups received only MCMV or CP. Animals were killed at 16 weeks of age to determine lesion area. Infection with MCMV alone, CP alone, and both MCMV and CP increased lesion size 84% (P