ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity.
ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity.
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HDL 中 ApoCIII 的富集会损害 HDL 介导的胆固醇流出能力
DOI：
10.1038/s41598-017-02601-7
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发表时间：
2017-05-24
影响因子：
4.6
通讯作者：
Peng D
中科院分区：
文献类型：
--
作者：
Luo M;Liu A;Wang S;Wang T;Hu D;Wu S;Peng D
载脂蛋白CIII（apoCIII）与甘油三酯代谢及冠心病易感性密切相关。此外，还发现apoCIII影响HDL的抗凋亡作用。然而，apoCIII对HDL介导的胆固醇流出（HDL的关键功能）的影响尚未报道。进行了一项以医院为基础的病例对照研究，以比较冠心病患者和非冠心病对照者脂蛋白中apoCIII的分布，并探讨HDL相关apoCIII（apoCIII HDL）与HDL介导的胆固醇流出之间的关系。140例冠心病患者和9例非冠心病对照者被纳入研究。测定血浆apoCIII、apoCIII HD和胆固醇流出能力。冠心病组apoCIII HDL/血浆apoCIII比值（0.52 ± 0.24vs.0.43 ± 0.22，P = 0.004）显著高于对照组。载脂蛋白C III高密度脂蛋白和载脂蛋白C III高密度脂蛋白比值与胆固醇流出能力呈负相关（分别为r =-0.241，P = 0.0002; r =-0.318，P < 0.0001）。逐步多元回归分析显示，apoCIII HDL比率是HDL介导的胆固醇流出能力的独立贡献者（标准化β =-0.325，P < 0.001）。本研究提示apoCIII在HDL中的存在可能影响HDL介导的胆固醇外排能力，提示apoCIII在动脉粥样硬化形成中的替代作用。
Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However, the effect of apoCIII on HDL-mediated cholesterol efflux, the crucial function of HDL, has not been reported. A hospital-based case-control study was conducted to compare the apoCIII distribution in lipoproteins between CAD patients and nonCAD controls and to explore the relationship between HDL-associated apoCIII (apoCIIIHDL) and HDL-mediated cholesterol efflux. One hundred forty CAD patients and nighty nine nonCAD controls were included. Plasma apoCIII, apoCIIIHDLand cholesterol efflux capacity was measured. The apoCIIIHDLratio (apoCIIIHDLover plasma apoCIII) was significantly higher in CAD patients than that in control group (0.52 ± 0.24 vs. 0.43 ± 0.22, P = 0.004). Both apoCIIIHDLand apoCIIIHDLratio were inversely correlated with cholesterol efflux capacity (r = −0.241, P = 0.0002; r = −0.318, P < 0.0001, respectively). Stepwise multiple regression analysis revealed that the apoCIIIHDLratio was an independent contributor to HDL-mediated cholesterol efflux capacity (standardized β = −0.325, P < 0.001). This study indicates that the presence of apoCIII in HDL may affect HDL-mediated cholesterol efflux capacity, implying the alternative role of apoCIII in the atherogenesis.