Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death
Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death
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β-分泌酶抑制剂对大鼠视网膜神经节细胞死亡的神经保护作用
DOI：
10.1016/j.neulet.2004.07.087
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发表时间：
2004
影响因子：
2.5
通讯作者：
H. Hara
中科院分区：
文献类型：
--
作者：
R. Yamamoto;S. Yoneda;H. Hara
β-分泌酶是一种参与淀粉样β-肽生成的酶，被认为与阿尔茨海默病的发病机制有关。我们研究了β-分泌酶抑制剂如N-苄氧羰基-Val-Leu-leucinal（Z-VLL-CHO）和H-EVN他汀VAEF-NH 2（GL-189）对谷氨酸诱导的体外视网膜神经节细胞（RGC）死亡的影响。在新生大鼠纯化RGC培养物中，暴露于25μM谷氨酸2天可诱导RGC死亡，Z-VLL-CHO（100 nM）和GL-189（1μM）具有神经保护作用。我们还发现Z-VLL-CHO对体内视神经挤压诱导的视网膜损伤显示出神经保护作用。因此，β-分泌酶可能成为治疗视网膜神经变性疾病的潜在靶点。
β-Secretase, an enzyme participating in amyloid β-peptide generation, is thought to be involved in the pathogenesis of Alzheimer's disease. We examined the effects of β-secretase inhibitors such as N-benzyloxycarbonyl-Val-Leu-leucinal (Z-VLL-CHO) and H-EVNstatineVAEF-NH2(GL-189) on glutamate-induced retinal ganglion cell (RGC) death in vitro. In cultures of purified RGCs from neonatal rats, 2-day exposure to 25μM glutamate induced RGC death, and Z-VLL-CHO (100nM) and GL-189 (1μM) had neuroprotective effects. We also found out that Z-VLL-CHO showed a neuroprotective effect on retinal damage induced by optic nerve crush in vivo. Thus, β-secretase could be a potential target for therapy of neurodegenerative retinal diseases.
影响因子：
4.4
作者：
S. Mckinnon;D. Lehman;Lisa A. Kerrigan-Baumrind;C. Merges;M. Pease;Danielle F. Kerrigan;N. Ransom;N. Tahzib;H. Reitsamer;H. Levkovitch-Verbin;H. Quigley;D. Zack
通讯作者：
S. Mckinnon;D. Lehman;Lisa A. Kerrigan-Baumrind;C. Merges;M. Pease;Danielle F. Kerrigan;N. Ransom;N. Tahzib;H. Reitsamer;H. Levkovitch-Verbin;H. Quigley;D. Zack