Association between C-reactive protein and features of the metabolic syndrome -: A population-based study
Association between C-reactive protein and features of the metabolic syndrome -: A population-based study
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DOI：
10.2337/diacare.23.12.1835
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发表时间：
2000-12-01
期刊：
影响因子：
16.2
通讯作者：
Koenig, W
中科院分区：
文献类型：
--
作者：
Fröhlich, M;Imhof, A;Koenig, W
研究设计和方法-总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）、甘油三酯、尿酸、体重指数（BMI）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、高密度脂蛋白胆在参与以人口为基础的国家健康和营养调查的747名男性和956名女性中评估了糖尿病和高血压的患病率，结果-C反应蛋白与TC（R = 0.19）、TG（R = 0.29）、BMI（R = 0.32）、葡萄糖（R = 0.11）和尿酸（R = 0.14）呈统计学显著正相关（均P < 0.0001）。C反应蛋白与高密度脂蛋白胆固醇呈负相关（R = 0.13，P < 0.0001）。根据存在0-1、2-3和大于或等于4个代谢综合征特征分组的受试者中，年龄校正的C反应蛋白浓度几何平均值分别为1.11、1.27和2.16 mg/l，在统计学上，结论：数据提示代谢综合征的多种特征与全身炎症反应有关。
OBJECTIVE - To assess the association of circulating levels of C-reactive protein, a sensitive systemic marker of inflammation, with different components of the metabolic syndrome.RESEARCH DESIGN AND METHODS - Total cholesterol (TC), HDL cholesterol, triglycerides, uric acid, BMI, and prevalence of diabetes and hypertension were assessed in 747 men and 956 women aged 18-89 years who were participating in the population-based National Health and Nutrition Survey, which was carried out in former West Germany in 1987-1988.RESULTS - There was a statistically significant positive crude correlation between C-reactive protein and TC (R = 0.19), TG (R = 0.29), BMI (R = 0.32), glucose (R = 0.11), and uric acid (R = 0.14) (all P < 0.0001). A negative correlation was found between C-reactive protein and HDL cholesterol (R = 0.13, P < 0.0001). The age-adjusted geometric means of C-reactive protein concentrations in subjects grouped according to the presence of 0-1, 2-3, and greater than or equal to4 features of the metabolic syndrome were 1.11, 1.27, and 2.16 mg/l, respectively, with a statistically highly significant trend (P < 0.0001).CONCLUSIONS - The data suggest that a variety of features of the metabolic syndrome are associated with a systemic inflammatory response.