Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque
Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque
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DOI：
10.1111/j.1550-7408.2006.00140.x
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Tzipori, Saul
中科院分区：
文献类型：
--
作者：
Akiyoshi, Donna E.;Weiss, Louis M.;Tzipori, Saul
比氏肠细胞虫是免疫功能低下人群中最常见和临床上最重要的与慢性腹泻和消瘦相关的微孢子虫。阿苯达唑对几种蠕虫、原生动物和微孢子虫有效，但对E.谢谢通过对大肠杆菌的序列分析，发现了对阿苯达唑临床耐药的可能解释。来自感染的人和自然感染的恒河猴的分离物的bieneusi β-微管蛋白。E. bieneusi在Glu（198）处具有取代，所述取代是报道的与苯并咪唑敏感性相关的六个氨基酸之一。
Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi beta-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The beta-tubulin of E. bieneusi has a substitution at Glu(198), which is one of six amino acids reported to be associated with benzimidazole sensitivity.