RESISTANCE FACTOR TO PLASMODIUM-VIVAX IN BLACKS - DUFFY-BLOOD-GROUP GENOTYPE, FYFY
RESISTANCE FACTOR TO PLASMODIUM-VIVAX IN BLACKS - DUFFY-BLOOD-GROUP GENOTYPE, FYFY
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DOI：
10.1056/nejm197608052950602
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发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
MCGINNISS, MH
中科院分区：
文献类型：
--
作者：
MILLER, LH;MASON, SJ;MCGINNISS, MH
达菲血型阴性的人红细胞FyFy能够抵抗体外诺氏疟原虫的侵袭。FyFy基因型主要在非洲和美国黑人中发现，他们是唯一完全抵抗间日疟原虫感染的群体。为了确定FyFy基因型是否为间日疟原虫抗性因子，对接触间日疟原虫感染蚊子叮咬的11名黑人和6名白人志愿者进行了血型检测。只有5株FyFy黑株对红细胞感染有抗性；其余6名黑人和所有白人都有达菲阳性决定因子（Fya或Fyb或两者都有）并感染疟疾。间日疟原虫分裂子侵入红细胞需要红细胞表面的达菲决定因子（Fya或Fyb或两者都有）。
Duffy-blood-group-negative human erythrocytes, FyFy, are resistant to invasion in vitro by P. knowlesi. The FyFy genotype is found predominantly in African and American blacks, who are the only groups completely resistant to infection by P. vivax. To determine if the FyFy genotype is the vivax resistance factor, blood typing was performed on 11 black and 6 white volunteers who were exposed to the bites of P. vivax-infected mosquitoes. Only the 5 FyFy blacks were resistant to erythrocytic infection; the remaining 6 blacks and all whites had the Duffy-positive determinants (Fya or Fyb or both) and contracted malaria. Duffy determinants (Fya or Fyb or both) on the erythrocyte surface are required for invasion of erythrocytes by vivax merozoites.